Evidence map›Paper›PMID 42516365›Full record

ArticleFrontiers in immunology2026

Case Report: Hemophagocytic lymphohistiocytosis secondary to

Ziping Liu, Fengjian Li, Yunhong Liu, Xueyan Chen

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ziping LiuDepartment of Clinical Laboratory Medicine, The People's Hospital of Longhua, Shenzhen, Guangdong, China.
Fengjian LiDepartment of Clinical Laboratory Medicine, The People's Hospital of Longhua, Shenzhen, Guangdong, China.
Yunhong LiuDepartment of Clinical Laboratory Medicine, The People's Hospital of Longhua, Shenzhen, Guangdong, China.
Xueyan ChenDepartment of Clinical Laboratory Medicine, The People's Hospital of Longhua, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a disorder characterized by dysregulated immune activation triggered by various etiologies, leading to excessive inflammatory responses, cytokine storm, and subsequent organ dysfunction. While the presence of hemophagocytic cells in septic shock is generally considered a physiological response that seldom requires specific intervention, the finding of abundant hemophagocytes along with

Indexed as

Antirheumatic AgentsArthritis, RheumatoidBone MarrowEscherichia coliEscherichia coli InfectionsLymphohistiocytosis, HemophagocyticMethotrexateUrinary Tract InfectionsFatal OutcomeFemaleHumansMiddle AgedAntirheumatic AgentsMethotrexateEscherichia coliimmunosuppressioninfiltration of bone marrowsecondary hemophagocytic lymphohistiocytosissepsis

Identifiers

PMID42516365
PMCPMC13402150

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.