ReviewFrontiers in immunology2026
The role of high-fiber diets in modulating the gut-lung axis and asthmatic inflammation.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
The gut microbiota is a key regulator of human health and disease, exhibiting considerable functional diversity. High-fiber diets are known to profoundly reshape the gut microbial composition and its metabolic output, notably enhancing the production of short-chain fatty acids (SCFAs). These SCFAs mediate communication along the gut-lung axis through multiple mechanisms, including epigenetic modifications, receptor-mediated signaling, and immunomodulation. Consequently, SCFAs promote regulatory T-cell expansion, restore Th1/Th2 balance, and alleviate airway inflammation in asthma. While clinical observations suggest that high-fiber intake can improve asthma symptoms and lung function, its long-term efficacy and generalizability across diverse populations require further investigation. Elucidating the mechanisms of microbial metabolites within the gut-lung axis through multi-omics integration represents a promising option for developing targeted nutritional interventions, particularly for pediatric and treatment-resistant asthma.
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