ArticleFrontiers in nephrology2026
Case Report: Renal sarcoidosis coexisting with membranous and IgA nephropathy, a very uncommon association.
Article in Frontiers in nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Sarcoidosis is a multisystemic inflammatory disease of unknown etiology with more frequent lung and lymph node involvement. Despite kidney involvement occurring between 25% and 43%, it may be underdiagnosed, with interstitial granulomatous nephritis and nephrocalcinosis being the most common features, and glomerular disease being less frequent. Case report: A 43-year-old man came to the emergency room (ER) because of macroscopic hematuria, arthralgias, pitting inferior extremities edema, asthenia, and dry cough without dyspnea. Evaluation revealed nephrotic range proteinuria and glomerular hematuria, suggesting an impure nephrotic syndrome. The kidney biopsy showed features of membranous nephropathy and granulomatous interstitial nephritis, with immunofluorescence showing codominant mesangial immunoglobulin A (IgA) and immunoglobulin G (IgG) deposits. Management and outcome: Steroids plus angiotensin receptor blocker (ARB) antagonists were effective, with symptoms subsiding and proteinuria level decreasing after 8 months of follow-up.
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