ArticleFrontiers in physiology2026
Decoding thermal adaptation: genome-wide identification of TRP channel repertoire in cephalopods and gene expression responses to chronic thermal exposure in
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Transient Receptor Potential (TRP) channels constitute a versatile family of membrane proteins central to sensory perception and a broad range of physiological functions. Conserved throughout evolution in both vertebrates and invertebrates, TRPs respond to diverse environmental stimuli, including temperature fluctuations, mechanical forces, osmotic changes, redox states, and chemical signals. In cephalopods, marine invertebrates renowned for their sophisticated sensory systems and behavioural complexity, the molecular mechanisms underlying thermal sensing remain poorly investigated. In this study, we present the first genome-wide identification and phylogenetic classification of 157 candidates TRP channel sequences among them 117 previously unannotated from 13 cephalopod species. These sequences were phylogenetically assigned to seven major TRP channel families (TRPA, TRPN, TRPC, TRPM, TRPV, TRPML, and TRPP). We further analysed TRP gene expression under chronic thermal stress in embryos of
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