ArticleFrontiers in nutrition2026
WCRF/AICR dietary adherence-associated metabolic bridge phenotypes and incident lung cancer risk: a prospective cohort study of the UK Biobank.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Lung cancer is the leading cause of cancer-related mortality worldwide. Although the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) dietary recommendations are widely endorsed, their association with lung cancer risk and related circulating metabolic phenotypes remains unclear. Methods: We derived a UK Biobank-adapted WCRF/AICR dietary adherence score from six components. Among 91,917 participants with complete dietary, covariate, follow-up, and metabolomic data, we constructed a diet-related plasma metabolomic signature and an FDR-restricted bridge score. Cox and Fine-Gray models examined associations with incident lung cancer, with Benjamini-Hochberg correction applied to high-dimensional analyses. Results: Over follow-up, 470 incident lung cancer cases occurred. The dietary score was not significantly associated with lung cancer risk. In contrast, the metabolomic signature was associated with lower risk in both Cox (HR per 1-SD: 0.816, 95% CI: 0.752-0.885; Conclusion: The questionnaire-based dietary score was not directly associated with lung cancer risk, whereas a plasma metabolomic signature showed a consistent inverse association. Fatty acid compositional measures may represent candidate metabolic biomarkers linking diet to lung cancer risk. These associative findings suggest that metabolic profiling may complement dietary questionnaires in future studies.
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