ArticleFrontiers in behavioral neuroscience2026
Sex-specific effects of prenatal methamphetamine exposure on activity and blood pressure in aged offspring.
Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methamphetamine use during pregnancy is a global health issue, and there is limited knowledge on the cardiovascular and behavioral effects of prenatal methamphetamine exposure in adults. This study investigated how prenatal methamphetamine exposure in rats, via maternal intravenous self-administration, affected methamphetamine sensitivity and cardiovascular function in aged offspring compared to controls. Methods: The aged offspring were generated from dams either self-administering methamphetamine daily under extended-access conditions before and throughout pregnancy, or their respective sham control dams. Spontaneous and methamphetamine-induced locomotor activity was assessed in male and female offspring of both exposure groups after a range of methamphetamine doses at age 15-17 months. Cardiovascular function was assessed in male and female offspring aged 18-20 months of both groups. Results: Baseline blood pressure and angiotensin II (AngII)-induced hypertension were determined non-invasively via tail cuff measurements. Methamphetamine dose-dependently increased locomotor activity compared to baseline activity in both sexes and both exposure groups. In both sexes, AngII did not increase diastolic or systolic blood pressure in methamphetamine-exposed offspring, yet induced hypertension in controls. Methamphetamine administration induced dose-dependent hyperactivity in both exposure groups, with methamphetamine-exposed offspring showing resistance to stereotypic effects and thus increased activity at 3.2 mg/kg compared to controls. Notably, methamphetamine-exposed female offspring had a tendency to hypertension at baseline, driven by higher diastolic blood pressure, and showed reduced hyperactivity compared to controls at 1.0 mg/kg. Males did not exhibit these changes. Conclusion: These findings suggest that aged female offspring are particularly sensitive to the impacts of prenatal methamphetamine exposure on blood pressure and methamphetamine sensitivity.
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