Evidence map›Paper›PMID 42516127›Full record

ReviewDementia & neuropsychologia2026

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI) in Alzheimer's disease: a scoping review of proteomic alterations in neurological tissues.

Gustavo Hayasaki Vieira, Victor Herlys Gomes Braga, Isabela Maciel Mesquita, Samara Silva Rodrigues, Samira Dionísio Maia, Giovana de Oliveira Araújo, Isadora Marra de Sá Sousa, Amarildo Lemos Dias de Moura

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dementia & neuropsychologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gustavo Hayasaki VieiraPontifícia Universidade Católica de Goiás, Faculdade de Medicina, Escola de Ciências Médicas e da Vida, Goiânia GO, Brazil.ORCID https://orcid.org/0009-0005-6759-1946
Victor Herlys Gomes BragaUniversidade Federal de Uberlândia, Faculdade de Medicina, Uberlândia MG, Brazil.ORCID https://orcid.org/0000-0002-6673-2728
Isabela Maciel MesquitaPontifícia Universidade Católica de Goiás, Faculdade de Medicina, Escola de Ciências Médicas e da Vida, Goiânia GO, Brazil.ORCID https://orcid.org/0009-0005-6220-4206
Samara Silva RodriguesPontifícia Universidade Católica de Goiás, Faculdade de Medicina, Escola de Ciências Médicas e da Vida, Goiânia GO, Brazil.ORCID https://orcid.org/0009-0001-0920-3344
Samira Dionísio MaiaPontifícia Universidade Católica de Goiás, Faculdade de Medicina, Escola de Ciências Médicas e da Vida, Goiânia GO, Brazil.ORCID https://orcid.org/0009-0004-5872-2476
Giovana de Oliveira AraújoPontifícia Universidade Católica de Goiás, Faculdade de Medicina, Escola de Ciências Médicas e da Vida, Goiânia GO, Brazil.ORCID https://orcid.org/0009-0003-7727-8860
Isadora Marra de Sá SousaPontifícia Universidade Católica de Goiás, Faculdade de Medicina, Escola de Ciências Médicas e da Vida, Goiânia GO, Brazil.ORCID https://orcid.org/0009-0002-5135-6018
Amarildo Lemos Dias de MouraPontifícia Universidade Católica de Goiás, Faculdade de Medicina, Escola de Ciências Médicas e da Vida, Goiânia GO, Brazil.ORCID https://orcid.org/0000-0002-1029-145X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has become a valuable tool for molecular mapping in neurological disorders. This scoping review synthesized current evidence on its use in proteomic analysis of neural tissues in Alzheimer's disease (AD). From 1,419 screened records, 26 studies met the inclusion criteria. Findings highlight MALDI-MS's capacity to detect beta-amyloid (Aβ) proteoforms, and tau protein post-translational modifications linked to AD. Its high spatial resolution enables region-specific molecular profiling, enhancing understanding of AD pathophysiology and supporting early biomarker discovery. The review underscores the translational potential of MALDI-MS in advancing targeted therapeutic development.

Indexed as

Alzheimer DiseaseCentral Nervous System DiseasesMass SpectrometryProteomics

Identifiers

PMID42516127
PMCPMC13403519

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.