Evidence map›Paper›PMID 42515653›Full record

ArticleViruses2026

Toxic Relationships: Characterization of a Putative Virally Encoded Toxin in the Thermophilic Archaeal Fusellovirus SSV1.

Jonathan C Abshier, Patrizia L Alpapara, Guasåli Tomokane, Kenneth M Stedman

Abstract read
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jonathan C AbshierCenter for Life in Extreme Environments and Biology Department, Portland State University, Portland, OR 97201, USA.ORCID 0000-0003-1814-6203
Patrizia L AlpaparaCenter for Life in Extreme Environments and Biology Department, Portland State University, Portland, OR 97201, USA.
Guasåli TomokaneCenter for Life in Extreme Environments and Biology Department, Portland State University, Portland, OR 97201, USA.
Kenneth M StedmanCenter for Life in Extreme Environments and Biology Department, Portland State University, Portland, OR 97201, USA.ORCID 0000-0001-6086-0238

Funding

Determining the molecular basis for extreme virus stability, a structure-guided approachR16GM154184 · NIGMS · PORTLAND STATE UNIVERSITY · PI Kenneth Mark Stedman · 2024 to 2026
$448k
UltracentrifugeS10GM154263 · NIGMS · PORTLAND STATE UNIVERSITY · PI STEDMAN, KENNETH MARK · 2024 to 2024
$99k
NIGMS NIH HHS R16 GM154184NIGMS NIH HHS S10 GM154263NIH HHS 1R16GM154184-01NIH HHS 1S10GM154263-01Portland State University NAUS Department of Education P031L220008U.S. National Science Foundation EES-1911026U.S. National Science Foundation MCB-1929273
6 · The paper itself

Abstract

Mechanisms for the maintenance of chronic viruses are poorly understood, particularly for archaeal viruses. Here, we identify the product of Sulfolobus spindle-shaped virus 1 (SSV1) ORF a291 as a putative virally encoded toxin required for growth inhibition but dispensable for viral replication and virion production. Viruses lacking ORF a291 replicated their genomes and formed morphologically normal spindle-shaped particles, yet failed to inhibit the growth of uninfected

Indexed as

FuselloviridaeSulfolobus solfataricusViral ProteinsAmino Acid SequenceGenome, ViralOpen Reading FramesVirus ReplicationViral Proteinsarchaeaarchaeal virusesextremophilestoxin–antitoxin systemsviral toxin

Identifiers

PMID42515653
PMCPMC13431529

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.