ArticleViruses2026
Increasing Frequency of Secondary Dengue Infections in Sequential Outbreaks (2016-2024)-Clinical Impact and Diagnostic Challenges.
Sonia L Espindola, Matías Javier Pereson, José Martín Lema, Analía Kachuk, Graciela M Carballo, Natalia Aloisi, María Noel Badano, Marcos Miretti, Federico A Di Lello, Patricia Baré
Abstract read
In one paragraphArticle in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Sonia L EspindolaLaboratorio GIGA, Instituto de Biología Subtropical (IBS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Exactas Químicas y Naturales, Universidad Nacional de Misiones (UNaM), Posadas 3300, Argentina.
Matías Javier PeresonInstituto de Medicina Experimental (IMEX), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Academia Nacional de Medicina, Buenos Aires 1425, Argentina.ORCID 0000-0002-7842-8838 José Martín LemaInstituto de Investigaciones Hematológicas (IIHEMA), Academia Nacional de Medicina, Buenos Aires 1425, Argentina.
Analía KachukLaboratorio GIGA, Instituto de Biología Subtropical (IBS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Exactas Químicas y Naturales, Universidad Nacional de Misiones (UNaM), Posadas 3300, Argentina.
Graciela M CarballoLaboratorios CEBAC SRL, Posadas 3300, Argentina.
Natalia AloisiInstituto de Investigaciones Hematológicas (IIHEMA), Academia Nacional de Medicina, Buenos Aires 1425, Argentina.
María Noel BadanoInstituto de Medicina Experimental (IMEX), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Academia Nacional de Medicina, Buenos Aires 1425, Argentina.
Marcos MirettiLaboratorio GIGA, Instituto de Biología Subtropical (IBS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Exactas Químicas y Naturales, Universidad Nacional de Misiones (UNaM), Posadas 3300, Argentina.
Federico A Di LelloInstituto de Medicina Experimental (IMEX), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Academia Nacional de Medicina, Buenos Aires 1425, Argentina.ORCID 0000-0001-9771-9705 Patricia BaréInstituto de Medicina Experimental (IMEX), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Academia Nacional de Medicina, Buenos Aires 1425, Argentina.ORCID 0000-0002-6348-428X Funding
Fundación René Barón naUniversidad de Buenos Aires 20020220100115BA
6 · The paper itselfAbstract
Successive dengue virus (DENV) outbreaks progressively reshape population immunity, influencing disease expression and diagnostic performance. This study evaluated the impact of secondary infections across sequential outbreaks on disease severity markers, serotype dynamics, and the agreement between routinely used direct diagnostic methods. This retrospective study analyzed 976 serum samples from three outbreaks in Misiones, Argentina. Clinical and serotype analyses included 869 acute-phase dengue cases confirmed by at least one direct detection method (2016:
Indexed as
CoinfectionDengueDengue VirusDisease OutbreaksAdolescentAdultArgentinaChildFemaleHumansMaleMiddle AgedRetrospective StudiesSerogroupViral Nonstructural ProteinsYoung AdultViral Nonstructural Proteinsdengue virussecondary infectionserotypeseverity
Identifiers
PMID42515637
PMCPMC13431616
What OpenQuestion holds
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LicenceCC BY
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