Evidence map›Paper›PMID 42515626›Full record

Observational studyViruses2026

Distinctive Inflammatory Traits of Parvovirus B19 Infection Associated with Persisting Autoimmunity.

Anna Negri, Maria Chiara Gerardi, Gabriele D Gallina, Luca Moroni, Antonella Adinolfi, Mona-Rita Yacoub, Nicola Boffini, Marco Lanzillotta, Annalaura Fasiello, Claudia Cordini and 5 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anna NegriFaculty of Medicine, Università Vita-Salute San Raffaele, via Olgettina 58, 20132 Milan, Italy.ORCID 0009-0007-9225-0638
Maria Chiara GerardiUnit of Rheumatology, IRCCS Ospedale Niguarda, Piazza dell'Ospedale Maggiore, 3, 20162 Milan, Italy.
Gabriele D GallinaUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, via Olgettina 60, 20132 Milan, Italy.ORCID 0000-0003-4285-5966
Luca MoroniUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, via Olgettina 60, 20132 Milan, Italy.ORCID 0000-0001-8988-9106
Antonella AdinolfiUnit of Rheumatology, IRCCS Ospedale Niguarda, Piazza dell'Ospedale Maggiore, 3, 20162 Milan, Italy.
Mona-Rita YacoubFaculty of Medicine, Università Vita-Salute San Raffaele, via Olgettina 58, 20132 Milan, Italy.ORCID 0000-0003-2417-0410
Nicola BoffiniUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, via Olgettina 60, 20132 Milan, Italy.
Marco LanzillottaUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, via Olgettina 60, 20132 Milan, Italy.ORCID 0000-0002-4522-2921
Annalaura FasielloUnit of Rheumatology, IRCCS Ospedale Niguarda, Piazza dell'Ospedale Maggiore, 3, 20162 Milan, Italy.
Claudia CordiniUnit of Rheumatology, IRCCS Ospedale Niguarda, Piazza dell'Ospedale Maggiore, 3, 20162 Milan, Italy.
Enrica P BozzoloUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, via Olgettina 60, 20132 Milan, Italy.
Marco Matucci-CerinicFaculty of Medicine, Università Vita-Salute San Raffaele, via Olgettina 58, 20132 Milan, Italy.
Oscar Massimiliano EpisUnit of Rheumatology, IRCCS Ospedale Niguarda, Piazza dell'Ospedale Maggiore, 3, 20162 Milan, Italy.
Lorenzo DagnaFaculty of Medicine, Università Vita-Salute San Raffaele, via Olgettina 58, 20132 Milan, Italy.
Giuseppe A RamirezFaculty of Medicine, Università Vita-Salute San Raffaele, via Olgettina 58, 20132 Milan, Italy.ORCID 0000-0002-2889-366X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdult parvovirus B19 (B19V) infection occurs with cyclic outbreaks and can be associated with inflammatory manifestations mimicking or heralding the onset of systemic autoimmune diseases. Little is known about clinical traits distinguishing patients with transient vs. persisting manifestations.

methodsLeveraging data from the 2024 B19V infection outbreak, we set up a retrospective, multicentre, observational study investigating the epidemiology and clinical phenotypes of patients with B19V infection presenting to tertiary care for immune-mediated manifestations, including patients with pre-existing autoimmunity.

resultsA total of 39 B19V infections were identified, yielding an annual incidence of 1.78 cases/1000 patients. Autoimmune rheumatic diseases were pre-existing in 7/39 and newly diagnosed in 5/39. One patient was hospitalised. Arthritis was more frequent in new-onset (89%) than in pre-existing (14%;

conclusionB19V-associated new-onset autoimmunity may occur in one in six cases observed in tertiary immunology care, show distinct clinical features, and require significant immunosuppression.

Indexed as

Autoimmune DiseasesAutoimmunityErythema InfectiosumInflammationParvoviridae InfectionsParvovirus B19, HumanAdultAutoantibodiesFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesAutoantibodiesautoimmune diseasesepidemiologyoutbreakparvovirus B19

Identifiers

PMID42515626
PMCPMC13431566

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.