Evidence map›Paper›PMID 42515617›Full record

ArticleViruses2026

Molecular Characterization of Lineage IV Peste des Petits Ruminants Viruses in Sudan Isolated from Outbreaks Between 2015 and 2018 Suggests the Existence of the North-East Africa Episystem.

Rayan M Asil, Arnaud Bataille, Martin Ludlow, Albert D M E Osterhaus, Abdelgadir Ballal, Salma O Abdelgadir, Muzdalifa A Hassan, Yahia H Ali, Saafass Alsarraj, Felix Njeumi and 2 more

Abstract read
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In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Rayan M AsilDepartment of Pathology, Parasitology and Microbiology, College of Veterinary Medicine, Sudan University of Science and Technology, Khartoum-North P.O. Box 204, Sudan.
Arnaud BatailleCIRAD, UMR ASTRE, 34398 Montpellier, France.ORCID 0000-0002-3508-2144
Martin LudlowResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0002-0061-1106
Albert D M E OsterhausResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0001-6535-3497
Abdelgadir BallalCentral Veterinary Research Laboratory (CVRL), Viral Vaccine Production Department, Khartoum P.O. Box 8067, Sudan.
Salma O AbdelgadirCentral Veterinary Research Laboratory (CVRL), Virology Department, Khartoum P.O. Box 8067, Sudan.
Muzdalifa A HassanCentral Veterinary Research Laboratory (CVRL), Virology Department, Khartoum P.O. Box 8067, Sudan.
Yahia H AliCentral Veterinary Research Laboratory (CVRL), Virology Department, Khartoum P.O. Box 8067, Sudan.ORCID 0000-0003-4132-4020
Saafass AlsarrajCentral Veterinary Research Laboratory (CVRL), Viral Vaccine Production Department, Khartoum P.O. Box 8067, Sudan.
Felix NjeumiFood and Agriculture Organization of the United Nations (FAO), Viale delle Terme di Caracalla, 00153 Rome, Italy.
Satya ParidaFood and Agriculture Organization of the United Nations (FAO), Viale delle Terme di Caracalla, 00153 Rome, Italy.ORCID 0000-0001-8253-9461
Nussieba A OsmanDepartment of Pathology, Parasitology and Microbiology, College of Veterinary Medicine, Sudan University of Science and Technology, Khartoum-North P.O. Box 204, Sudan.ORCID 0000-0001-6224-8376

Funding

Food and Agriculture Organization of the United Nations SUD/TCP/3504Sudanese Ministry of Higher Education and Scientific Research, Commission of Scientific Research and Innovation MOHE-SRI-2017-972
6 · The paper itself

Abstract

Multiple outbreaks with high mortality rates and a pattern of disease occurrence similar to peste des petits ruminants (PPR) were observed in sheep and goats across many states of Sudan between 2015 and 2018. Therefore, this study aimed to investigate and identify the cause of these disease outbreaks. A total of 276 blood and lung tissue samples were collected from infected sheep (n = 223) and goats (n = 53). Sample analysis in an IC-ELISA revealed the presence of the PPRV antigen in 56.9% of sheep and 62.3% of goat samples. Twenty-seven [sheep (18) and goats (9)] PPRV-positive samples from IC-ELISA were subsequently confirmed positive using the PPRV N-gene-based RT-PCR. Two PPR viruses were isolated from infected small ruminant lung tissues in Vero cells. The partial N-gene sequences for five PPRV strains originating from sheep and goats were determined. Phylogenetic tree grouped PPRV strains identified in this study in lineage IV in sub-lineage NEA (North-East Africa), with the highest sequence identity observed with strains circulating in North African countries. This study and earlier published phylogenetic analysis and patterns of animal movements suggest that the transboundary transmission of PPRV lineage IV strains between East and North African countries has been happening since 2008 and established a new North-East Africa episystem that needs to be disrupted for the successful global eradication of PPR.

Indexed as

Disease OutbreaksGoat DiseasesPeste-des-Petits-RuminantsPeste-des-petits-ruminants virusSheep DiseasesAnimalsGoatsPhylogenySheepSudanepisystemMorbillivirusnucleoprotein geneoutbreakspeste des petits ruminants (PPR)phylogeneticssmall ruminantsSudan

Identifiers

PMID42515617
PMCPMC13431533

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.