Procyanidins A1 and B1 Suppress PEDV CV777 by Modulating Mitophagy.

Yujing Weng, Jialin Li, Cong Ma, Jiufeng Wang, Xiaojia Wang

Abstract read

In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yujing WengNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

Jialin LiNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

Cong MaHealth Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.

Jiufeng WangNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-0183-5611

Xiaojia WangNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0001-9183-0023

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV) causes severe enteric disease and high mortality in piglets, yet effective therapeutic options remain scarce. To identify novel antivirals, we evaluated the inhibitory potential and molecular mechanisms of four procyanidin subtypes (A1, A2, B1, and B2) in Vero cells. Our results indicate that procyanidins A1 and B1 possess superior anti-PEDV activity compared with their analogs, acting primarily through direct virucidal inactivation (

Indexed as

Antiviral AgentsBiflavonoidsCatechinMitophagyPorcine epidemic diarrhea virusProanthocyanidinsAnimalsChlorocebus aethiopsCoronavirus InfectionsMitochondrial DynamicsMolecular Docking SimulationSwineUbiquitin-Protein LigasesVero CellsVirus InternalizationVirus ReplicationAntiviral AgentsBiflavonoidsCatechinProanthocyanidinsprocyanidin B1Ubiquitin-Protein Ligasesmitophagymolecular dockingporcine epidemic diarrhea virusprocyanidin

Identifiers

PMID42515610

DOI10.3390/v18070758

PMCPMC13431556

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.