Evidence map›Paper›PMID 42515608›Full record

ReviewViruses2026

Plant-Derived Anti-TMV Metabolites: Mechanisms, Limitations and Future Perspectives.

Muhammad Qasim Aslam, Ziran Gao, Amr Said Mohamed, Samah Mostafa El-Sayed, Wenjing Yang, Lin Cheng, Kuo Wu, Yu Li, Yongdui Chen

Abstract readReview
In one paragraph

Review in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muhammad Qasim AslamBiotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Yunnan Provincial Key Laboratory of Agricultural Biotechnology/Key Lab of Southwestern Crop Gene Resource and Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Kunming 605205, China.ORCID 0000-0001-9861-1595
Ziran GaoBiotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Yunnan Provincial Key Laboratory of Agricultural Biotechnology/Key Lab of Southwestern Crop Gene Resource and Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Kunming 605205, China.
Amr Said MohamedBiotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Yunnan Provincial Key Laboratory of Agricultural Biotechnology/Key Lab of Southwestern Crop Gene Resource and Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Kunming 605205, China.ORCID 0000-0001-5844-4219
Samah Mostafa El-SayedOrnamental Plants and Woody Trees Department, Agricultural and Biological Research Institute, National Research Centre, Giza 12513, Egypt.ORCID 0000-0001-6995-9402
Wenjing YangBiotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Yunnan Provincial Key Laboratory of Agricultural Biotechnology/Key Lab of Southwestern Crop Gene Resource and Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Kunming 605205, China.
Lin ChengBiotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Yunnan Provincial Key Laboratory of Agricultural Biotechnology/Key Lab of Southwestern Crop Gene Resource and Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Kunming 605205, China.
Kuo WuBiotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Yunnan Provincial Key Laboratory of Agricultural Biotechnology/Key Lab of Southwestern Crop Gene Resource and Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Kunming 605205, China.
Yu LiBiotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Yunnan Provincial Key Laboratory of Agricultural Biotechnology/Key Lab of Southwestern Crop Gene Resource and Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Kunming 605205, China.ORCID 0000-0002-3439-3530
Yongdui ChenBiotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Yunnan Provincial Key Laboratory of Agricultural Biotechnology/Key Lab of Southwestern Crop Gene Resource and Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Kunming 605205, China.

Funding

National Natural Science Foundation of China 31860498National Natural Science Foundation of China 32360638the Basic Research General Project of Science and Technology, Department of Yunnan Province 202501AT070087Yunnan Revitalization Talent Support Project XDYC-CYCX-2022-0065
6 · The paper itself

Abstract

Tobacco mosaic virus (TMV) poses a serious threat to global agricultural production. It is an exceptionally stable virus with a broad host range and is widespread across diverse agroecosystems. Concerning TMV management, plant-derived metabolites have emerged as promising and eco-friendly antiviral agents. To date, numerous plant-derived metabolites with potent anti-TMV activity and their underlying mechanisms of action have been identified. However, a comprehensive understanding of their mechanisms of action is still lacking. This review summarizes the diversity of anti-TMV mechanisms triggered by natural and plant-sourced semisynthetic compounds. These metabolites mainly include alkaloids, flavonoids, terpenoids, phenylpropanoids, and glycosides, which act either directly targeting virus particles or indirectly by eliciting host immunity. Together, these mechanisms form an integrated defence network that restricts viral replication and movement within the host. This mechanistic understanding will be essential for the rational development of sustainable and effective plant-derived antiviral agents.

Indexed as

Antiviral AgentsPlant DiseasesPlantsTobacco Mosaic VirusAlkaloidsFlavonoidsTerpenesVirus ReplicationAlkaloidsAntiviral AgentsFlavonoidsTerpenesanti-TMV activityantiviral mechanismscoat protein and induce resistanceplant-derived compoundstobacco mosaic virus

Identifiers

PMID42515608
PMCPMC13431632

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.