SynthesisViruses2026
Prevalence and Variability of Clinical Manifestations of Dengue in Peru: A Systematic Review and Meta-Analysis of Observational Studies.
Synthesis in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Dengue remains a major public health challenge in Peru, where recurrent outbreaks show marked variation in clinical presentation. This systematic review and meta-analysis synthesized available evidence to quantify the frequency and variability of dengue manifestations in Peruvian patients and to identify clinically relevant patterns for early recognition. We systematically searched PubMed, Scopus, Embase, Web of Science, ScienceDirect, Google Scholar, Virtual Health Library, and Scielo for observational studies published between 1993 and January 2025. Two reviewers independently selected studies, extracted data, and assessed methodological quality. Pooled prevalence estimates with 95% confidence intervals (CIs) were calculated using random-effects models. Twenty-eight studies including 4418 patients were analyzed. The most frequent manifestations were fever (95%; 95% CI: 90-98%), headache (86%; 95% CI: 80-91%), malaise (82%; 95% CI: 71-91%), myalgia (69%; 95% CI: 58-79%), arthralgia (64%; 95% CI: 56-73%), and retro-orbital pain (56%; 95% CI: 47-66%). Gastrointestinal symptoms were also common, including nausea/vomiting (40%; 95% CI: 33-48%) and abdominal pain (33%; 95% CI: 21-45%), whereas hemorrhagic and severe manifestations were less frequent, such as hematemesis (6%; 95% CI: 2-10%), petechiae (6%; 95% CI: 2-10%), jaundice (3%; 95% CI: 1-7%), and melena (1%; 95% CI: 0-6%). Heterogeneity was high across most outcomes (I
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