ArticleViruses2026
Region-Specific Apoptosis-Related Gene Expression Is Uncoupled from Viral RNA Load in Canine Distemper Neuropathogenesis.
Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Canine distemper virus (CDV) is a highly contagious morbillivirus associated with severe neurological disease in dogs. Although apoptosis is recognized as an important mechanism in CDV-associated neurodegeneration, the relationship between regional viral RNA load and apoptosis-related transcriptional responses remains poorly defined. This study aimed to quantify CDV RNA load and the expression of apoptosis-related genes, including the pro-apoptotic markers Bax, caspase-3 and caspase-8 and the anti-apoptotic marker Bcl-2, in the frontal cortex, hippocampus, and cerebellum of 21 dogs naturally infected with CDV, compared with four neurologically normal controls. Viral RNA load and gene expression were assessed by quantitative reverse transcription PCR (qRT-PCR). CDV RNA was detected in all brain regions of infected dogs, with no significant differences in viral RNA load among the frontal cortex, hippocampus and cerebellum (
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