Evidence map›Paper›PMID 42515560›Full record

ArticleViruses2026

Differentiated Contact Tracing for Emerging Zoonotic Hantavirus and Ebolavirus Infections: Lessons from the 2026 Andes Virus (MV Hondius) and Bundibugyo Virus Outbreaks.

Francesco Broccolo, Massimiliano Galdiero

Abstract read
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Francesco BroccoloUOSD Virology and Microbiology, University Hospital P.O. Vito Fazzi-ASL Lecce, 73100 Lecce, Italy.ORCID 0000-0003-1297-2598
Massimiliano GaldieroDepartment of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.ORCID 0000-0002-1576-6290

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In May 2026, two outbreaks occurred at once: an Andes virus outbreak aboard the MV Hondius expedition cruise ship (13 cases (12 laboratory-confirmed and 1 probable), 3 deaths, and more than 600 contacts traced across 32 countries and territories; passengers and crew from 23 countries; data as of 22 June 2026) and a Bundibugyo virus disease (BDBV) outbreak in Central Africa (more than 1000 laboratory-confirmed cases and more than 250 confirmed deaths in the Democratic Republic of the Congo and Uganda; data as of 22 June 2026). The two pathogens diverge sharply in their transmission epidemiology. Aboard the MV Hondius, person-to-person transmission was sustained across three generations from a single index case, and one asymptomatic, PCR-positive contact later developed symptoms, indicating pre-symptomatic ANDV RNA detection, although the extent to which this corresponds to infectiousness and onward transmission remains uncertain. BDBV, on current evidence, has not been documented to sustain pre-symptomatic transmission as a major driver of its outbreaks, which allows for contact tracing of different timing and intensity. This Perspective draws together the epidemiological data from the MV Hondius outbreak, the endemic-region experience (Chile's 2021-2025 secondary attack rate of 5.7%; Argentina's 1996 El Bolsón and 2018 Epuyén outbreaks), the molecular pathogenesis, the diagnostic platforms, the therapeutic pipeline (favipiravir, tocilizumab, Icatibant) and the vaccine strategies (USAMRIID DNA vaccine, phase 1 completed). We set the contact-tracing and active-surveillance protocols applied to ANDV against the less stringent protocols that may suffice for BDBV.

Indexed as

Communicable Diseases, EmergingContact TracingDisease OutbreaksHantavirus InfectionsOrthohantavirusZoonosesAnimalsHumansactive surveillanceAndes virusasymptomatic transmissionBundibugyo viruscontact tracingfavipiravirhantavirus vaccineMV Hondiusperson-to- person transmissionpresymptomatic transmissionRT-qPCR diagnosticstocilizumab

Identifiers

PMID42515560
PMCPMC13431576

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.