SynthesisViruses2026
Person-to-Person Transmission of Andes Virus (ANDV): A Systematic Review of Transmission Dynamics, Viral Shedding, and Public Health Implications.
Synthesis in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Drivers of Viral Spillover: An Examination of How Pathogens Spread.Pathogens (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Andes virus (ANDV) is the only hantavirus with well-documented evidence of person-to-person transmission. However, key parameters related to transmission timing, viral shedding, exposure contexts, and public health management remain incompletely defined. We conducted a systematic review in accordance with PRISMA 2020. MEDLINE/PubMed, Scopus, and Web of Science were searched from database inception up to 14 May 2026. Eligible studies reported epidemiological, virological, clinical, or public health data relevant to ANDV infection, person-to-person transmission, viral shedding, and/or outbreak control. Thirty-three studies, including 17,204 individuals, 2221 laboratory-confirmed ANDV cases, and 135 documented secondary cases, were included. Person-to-person transmission was identified as a primary or co-occurring route in 20 papers. The median incubation period among ANDV cases was 20.8 days, and the median serial interval was 21.8 days (upper bounds near 40 days). Secondary attack rates were higher among sexual and other close contacts. ANDV RNA was consistently detected in blood and occasionally in saliva, respiratory secretions, urine, breast milk, and semen, although RNA detection alone does not necessarily imply infectious virus. Rare reports of culture-confirmed isolation of replication-competent virus support the biological plausibility of transmission via close mucosal or respiratory exposure. Unlike other hantaviruses, Andes virus can spread person to person through close contact, supporting prolonged monitoring and risk-stratified follow-up of high-risk contacts based on ANDV-specific epidemiological evidence. Possible recommendations, including post-discharge counselling regarding possible sexual transmission, remain provisional and require further evidence. Preparedness activities against outbreaks should also be implemented in non-endemic regions, while future research should prioritize prospective contact studies, standardized virological sampling, and genomic confirmation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.