Evidence map›Paper›PMID 42515544›Full record

ReviewViruses2026

Eastern Equine Encephalitis Virus Complex: Human Disease, Diagnosis and Treatment.

Mohammed Umar, Evan P Williams, Gabriel Correa Quitete Schaller Chagas, Anuj Singh, Katarina Rueda, Colleen B Jonsson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammed UmarDepartment of Microbiology, Immunology, Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0009-0009-7550-9286
Evan P WilliamsRegional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-4506-115X
Gabriel Correa Quitete Schaller ChagasDepartment of Microbiology, Immunology, Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0009-0002-7652-5340
Anuj SinghDepartment of Microbiology, Immunology, Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-2244-9258
Katarina RuedaDepartment of Microbiology, Immunology, Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Colleen B JonssonDepartment of Microbiology, Immunology, Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-2640-7672

Funding

Medicinal Chemistry Optimization of Anti-Alphaviral Leads and Elucidation of Target and Off Target EngagementU19AI142762 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GOLDEN, JENNIFER E. · 2019 to 2023
$22.0M
NIAID NIH HHS U19 AI142762
6 · The paper itself

Abstract

The Eastern equine encephalitis virus (EEEV) complex comprises mosquito-borne neurotropic alphaviruses maintained in nature by mosquitoes. Although rare, human infections caused by these viruses can lead to febrile illness that may progress to severe encephalitis, for which there are no vaccines for prevention and no specific therapeutics for treatment. Moreover, a high percentage of human cases show long-term neurological sequelae. Here, we review the literature on cases, diagnosis, and management. Current gaps in clinical care include an urgent need to develop rapid diagnostic tests, new therapeutics, and vaccines.

Indexed as

Encephalitis Virus, Eastern EquineEncephalomyelitis, Eastern EquineEncephalomyelitis, EquineAnimalsCulicidaeHumansalphavirusclinical symptomsdiagnosisEastern equine encephalitis virusMadariaga virusneurological sequelaepathology

Identifiers

PMID42515544
PMCPMC13431584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.