ArticleToxics2026
Animal-Free Skin Sensitization Testing: In Chemico and In Silico Integrated Approach.
Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing prohibition of animal testing for cosmetic products has driven the development of alternative approaches to ensure consumer safety. Skin sensitization is one of the most critical toxicological endpoints to evaluate, requiring rigorous assessment to ensure the safety of cosmetic ingredients. This study proposes an Integrated Testing Strategy (ITS) that combines in chemico (Direct Peptide Reactivity Assay-DPRA) and in silico approaches (a six-platform computational panel) to evaluate the sensitization potential of substances. Initially, the in chemico methodology was validated through a partial proficiency demonstration to ensure experimental reliability. Subsequently, this ITS was applied to the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.