Cytokine Indicators Associated with Disease Severity in Severe Fever with Thrombocytopenia Syndrome: A Systematic Review and Meta-Analysis.

Yaqi Xie, Quanman Hu, Shuaiyin Chen, Baoqin Zhang

Abstract readSystematic ReviewMeta-Analysis

In one paragraph

Synthesis in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Yaqi XieZhengzhou Center for Disease Control and Prevention, Zhengzhou 450001, China.

Quanman HuDepartment of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, No. 100-Kexue Avenue, Zhengzhou 450001, China.

Shuaiyin ChenDepartment of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, No. 100-Kexue Avenue, Zhengzhou 450001, China.ORCID 0000-0001-6129-0310

Baoqin ZhangZhengzhou Center for Disease Control and Prevention, Zhengzhou 450001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this study is to study cytokine indicators for the identification of severe fever with thrombocytopenia syndrome (SFTS) severity.

methodsWe searched the literature in PubMed, Embase, and Web of Science published before 7 April 2026. The main results are presented as forest plots. Subgroup analyses, sensitivity analyses, and publication bias were also performed.

resultsA total of 22 articles were eventually included in our study. Our findings demonstrate that circulating concentrations of Interleukin-6 (IL-6) (SMD = 2.02, 95% CI: 1.53-2.51, I

conclusionsBy analyzing the cytokine indicators of SFTS patients, we have found some indicators that are representative of SFTS severity. Our findings provide a clinically actionable basis for early severity prediction and further useful evidence for clinicians to manage severe patients efficiently.

Indexed as

CytokinesSevere Fever with Thrombocytopenia SyndromeBiomarkersHumansSeverity of Illness IndexTumor Necrosis Factor-alphaBiomarkersCytokinesTumor Necrosis Factor-alphacytokine indicatorsmeta-analysismild casessevere casessevere fever with thrombocytopenia syndrome

Identifiers

PMID42515082

DOI10.3390/pathogens15070755

PMCPMC13415233

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