Evidence map›Paper›PMID 42514692›Full record

ArticleVeterinary sciences2026

Genetic Evolution and Molecular Characterization of PRRSV GP5 in Germany.

Jiankun Pang, Qipeng Zhang, Chen Lv, Huawei Li, Xuyong Zhao, Ruining Wang, Keshan Zhang, Yaqiong Ye, Mengmeng Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiankun PangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528225, China.
Qipeng ZhangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528225, China.
Chen LvGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528225, China.
Huawei LiInstitute of Animal Product Quality and Safety Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Xuyong ZhaoInstitute of Animal Product Quality and Safety Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Ruining WangInstitute of Animal Product Quality and Safety Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Keshan ZhangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528225, China.ORCID 0009-0002-0306-0327
Yaqiong YeGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528225, China.
Mengmeng ZhaoGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528225, China.ORCID 0000-0003-4143-3606

Funding

Base and Talent Program of Science and Technology Plan in Tibet Autonomous Region XZ202401JD0012Foshan University 2025 Graduate Excellence and Innovation Program FOSU2025ZYCX-M04Foshan University High Level Talents Research Start-up Project CGZ07465/CGZ07001Guangdong Basic and Applied Basic Research Foundation 2024A1515140152Guangdong Provincial Department of Education's distinctive innovation initiative 2023KTSCX128Key Research and Development Special Project of Henan Province 251111113600Key Scientific and Technological Grants in Henan Province 24210211031National Key Research and Development Program Projects 2023YFD1801302, 2023YFD1801301Open Foundation of Guangdong Provincial Key Laboratory of Animal Molecular Design and Pre-cise Breeding 2024B03Special Funds for Rural Revitalization Strategy of Guangdong Provincial Department of Agriculture and Rural Affairs in 2024 2024CXTD15the National Natural Science Foundation of China 31902279
6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome (PRRS) has been prevalent in Germany for over 30 years, posing a significant threat to the local swine industry. There are limited analyses to offer German PRRSV ORF5 genetic and evolutionary characteristics and GP5 structural and functional features. In this study, a total of 518 sequences of the PRRSV GP5 gene were obtained from the GenBank database, encompassing 102 sequences from Germany to investigate the genetic relationships and GP5 structural and functional features. Similarly, phylogenetic and recombination analyses were used to identify genetic relationships. Two German PRRSV-1 lineage 1 strains exhibited more than 98.0% nucleotide similarity with vaccine strains. Eighteen German PRRSV-2 lineage 5 strains exhibited more than 98.0% nucleotide similarity with a prototype vaccine strain. German PRRSV-1 lineage 1 was predominant. GP5 structural and functional features were determined by N-glycosylation sites, B-cell epitopes, and transmembrane domain predictions. The main N-glycosylation patterns and transmembrane domains of German PRRSV-1 lineage 1 were time-dependent. Mutations of German PRRSV-1 lineage 3 in the primary neutralizing epitope were detected. In conclusion, these findings reveal lineage-specific molecular variation and improve the understanding of the molecular evolution of German PRRSV.

Indexed as

genetic variationGermanyGP5 genephylogenyporcine reproductive and respiratory syndrome virusrecombination

Identifiers

PMID42514692
PMCPMC13431494

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.