Evidence map›Paper›PMID 42514664›Full record

ArticleVeterinary sciences2026

Anti-Inflammatory and Metabolic Effects of Fresh Versus Freeze-Dried Platelet-Rich Plasma on Equine Osteoarthritis in an Ex Vivo Cartilage-Synovium Explant Co-Culture System: A Pilot Study.

Shiyu Duan, Zixuan Wang, Yuchen Jia, Xin'er Lan, Cong Peng, Xiyue Deng, Hui Jiang, Wei Wang, Guangzhi Zhong, Yiping Zhu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shiyu DuanEquine Clinical Diagnostic Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0001-5920-521X
Zixuan WangEquine Clinical Diagnostic Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0009-0006-4121-1762
Yuchen JiaEquine Clinical Diagnostic Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Xin'er LanEquine Clinical Diagnostic Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Cong PengEquine Clinical Diagnostic Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Xiyue DengEquine Clinical Diagnostic Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Hui JiangEquine Clinical Diagnostic Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Wei WangEquine Clinical Diagnostic Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Guangzhi ZhongEquine Clinical Diagnostic Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yiping ZhuEquine Clinical Diagnostic Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Jing LiEquine Clinical Diagnostic Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-1361-4525

Funding

Xinjiang Talent Development Fund ZZYD2025010
6 · The paper itself

Abstract

Equine osteoarthritis (OA) is a major cause of lameness and economic loss in horses. While platelet-rich plasma (PRP) has clinical potential, the biological effects of fresh PRP (F-PRP) and freeze-dried PRP (FD-PRP) remain insufficiently defined. This pilot study compared 25% and 50% F-PRP and FD-PRP in an interleukin-1β-induced equine cartilage-synovium explant co-culture model. PRP treatments reduced inflammatory responses, with significant downregulation of COX-2 and PGE2 expression, and 25% F-PRP showed the most consistent inhibition of nitric oxide production. PRP also significantly reduced glycosaminoglycan release and altered matrix-related gene expression; however, FD-PRP significantly upregulated

Indexed as

equine osteoarthritisinflammatory markersmetabolic pathwaysmetabolomicsplatelet-rich plasma

Identifiers

PMID42514664
PMCPMC13431378

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.