Evidence map›Paper›PMID 42514374›Full record

ArticleNutrients2026

BMI-Dependent Modulation of the Soluble RAGE-Sirtuin-1 Axis by Coffee Type in Coronary Artery Disease.

Alessandra Roggerio, Celia Maria Cassaro Strunz, Gabriela Parisi Polo, Luíz Antônio Machado César, Antonio De Padua Mansur

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In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alessandra RoggerioLaboratório de Análises Clínicas, Instituto Do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, Brazil.
Celia Maria Cassaro StrunzLaboratório de Análises Clínicas, Instituto Do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, Brazil.ORCID 0000-0002-9766-1184
Gabriela Parisi PoloUnidade de Coronariopatia Crônica, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, Brazil.
Luíz Antônio Machado CésarUnidade de Coronariopatia Crônica, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, Brazil.
Antonio De Padua MansurServiço de Prevenção, Cardiopatia na Mulher e Reabilitação Cardiovascular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/20582-8
6 · The paper itself

Abstract

backgroundCoffee contains bioactive compounds associated with cardiometabolic benefits, which modulate metabolic pathways of Sirtuin-1. The AGEs-RAGE axis promotes Sirtuin-1 degradation, but soluble RAGE (sRAGE) acts as a decoy receptor, modulating this signaling pathway. In this hypothesis-generating study, we explore whether relatively higher versus lower body mass index (BMI) phenotypes are associated with differential sRAGE responses to caffeinated and decaffeinated coffee in patients with coronary artery disease (CAD).

methodsThirty patients were allocated into two intervention-sequence groups that differed in mean BMI (

resultsSerum biomarkers remained unchanged; only Sirtuin-1 increased after caffeinated coffee (

conclusionsBMI appears to modulate the sRAGE response to coffee intake in CAD patients, with leaner individuals exhibiting a response that is highly dependent on the type of coffee consumed.

Indexed as

Body Mass IndexCoffeeCoronary Artery DiseaseReceptor for Advanced Glycation End ProductsSirtuin 1AgedBiomarkersBlood GlucoseCaffeineFemaleGlycated HemoglobinHumansMaleMiddle AgedBiomarkersBlood GlucoseCaffeineCoffeeGlycated HemoglobinReceptor for Advanced Glycation End ProductsSIRT1 protein, humanSirtuin 1caffeinated coffeecoronary artery disease (CAD)obesitySirtuin-1soluble RAGE

Identifiers

PMID42514374
PMCPMC13415449

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.