ArticleNutrients2026
Joint Dietary and Gut Microbial Profiling and the Fatty Liver Index in Community-Dwelling Older Japanese: A Cross-Sectional, Hypothesis-Generating Analysis from the Kyotango Longevity Study.
Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDiet and the gut microbiota are each associated with hepatic steatosis, but their joint variation and shared explanatory contribution are rarely quantified in older Asian community-dwelling populations.
methodsIn 701 non-heavy-drinking Kyotango longevity cohort adults, habitual diet (BDHQ; 31 food groups) and stool 16S rRNA microbiome (47 genera; CLR-transformed) were related to the fatty liver index (FLI) by canonical correlation analysis (CCA), reduced-rank regression (RRR), and bootstrap mediation; FIB-4 was a secondary exploratory outcome.
resultsFour dietary patterns and four microbial clusters emerged. CCA revealed multivariate diet-microbiota co-variation (four significant canonical correlations; r = 0.40-0.46; all
conclusionsIn this cross-sectional, hypothesis-generating analysis with no individual-level predictive utility, dietary patterns and gut microbial composition co-vary and jointly relate to FLI. The findings describe population-level covariance patterns for future prospective diet-microbiome intervention testing; external validation in independent cohorts is essential.
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