ReviewNutrients2026
Daily Calcium and Vitamin D Supplementation as a Foundational Pillar in Osteoporosis Management: A Narrative Review.
Review in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Osteoporosis is a progressive skeletal disorder characterized by decreased bone strength and an increased risk of fractures. It presents a high global prevalence, thus imposing a significant clinical and economic burden. This narrative review includes current evidence on the role of combined calcium and vitamin D supplementation in the management and prevention of osteoporosis, as well as its effect on reducing fracture risk and maintaining bone mineral density. It aims to provide an overview of osteoporosis pathophysiology, the importance of adequate calcium levels and 25-hydroxyvitamin D concentrations and the prevalence of their deficiencies. The review examines the evidence supporting combined supplementation and its importance in patients receiving anti-osteoporotic pharmacological therapies. Current clinical guidelines and consensus statements, along with their recommendations for dosing, formulation, and monitoring of calcium and vitamin D supplements, are included. Barriers to the effective implementation, gaps in clinical practice, patient adherence, and primary care challenges are discussed. Ultimately, this review examines the cost-effectiveness of supplementation and the areas for improvement in real-world evidence and research in the field of osteoporosis. This work aims to provide clinicians and healthcare professionals with an updated, evidence-based framework for optimizing calcium and vitamin D supplementation in the care of patients with osteoporosis.
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Registered trials
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