ArticleNutrients2026
The Associations Between Habitual Dietary Fat Intake and Inflammatory Markers Among Marathon Runners: An Exploratory Study.
Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundMarathon running triggers a robust systemic inflammatory response. Whether habitual dietary fat composition modulates pre-race cytokine concentrations or the magnitude and recovery of the exercise-induced inflammatory response remains unknown.
methodsThirty-one recreational marathon runners (58.1% female; mean age 38.4 ± 10.2 years) completed the Diet History Questionnaire III to assess habitual dietary fat intake-including chain-length-specific SFA, MFA, PFA, trans fatty acids, and CLA-over the preceding three months. Circulating IFN-γ, IL-1β, IL-4, IL-6, IL-10, and TNF-α were measured pre-race, immediately post-race, and 48 h post-race. Repeated measures ANOVA examined cytokine changes; multivariable regression models estimated fat-cytokine associations adjusted for 11 pre-specified covariates, with Benjamini-Hochberg FDR correction applied across all models.
resultsIL-6 rose markedly post-race (
conclusionsHabitual intake of the long-chain monounsaturated fatty acid 20:1 was positively associated with IFN-γ and TNF-α at 48 h post-race. This pattern, emerging specifically at the 48 h post-race phase, suggests that the post-race period, once acute exercise-induced signaling has subsided, may be a window in which habitual dietary fat quality is most detectable in relation to circulating cytokines. Habitual fat quality may warrant consideration in future endurance recovery nutrition research. This exploratory finding calls for replication in larger cohorts.
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