Evidence map›Paper›PMID 42514277›Full record

ArticleLife (Basel, Switzerland)2026

Early Pulmonary Stress During Intra-Abdominal Hypertension and Hypervolemia: Surfactant Protein A1 and Multi-Compartment Biomarker Responses in Rats.

Mert Canbaz, Halim Ulugöl, Gülsüm Karduz, Kübra Vardar, Mukadder Orhan Sungur, Evren Şentürk, Uğur Aksu, Pınar Fırat, Perihan Ergin Özcan, Fevzi Toraman and 2 more

Abstract read
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In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mert CanbazDepartment of Anesthesiology and Reanimation, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, Turkey.ORCID 0000-0003-3489-6944
Halim UlugölDepartment of Anesthesiology and Reanimation, School of Medicine, Acibadem University, Istanbul 34752, Turkey.ORCID 0000-0003-1647-6479
Gülsüm KarduzBiology Department, Science Faculty, Istanbul University, Istanbul 34134, Turkey.ORCID 0000-0002-0289-0401
Kübra VardarBiology Department, Science Faculty, Istanbul University, Istanbul 34134, Turkey.
Mukadder Orhan SungurDepartment of Anesthesiology and Reanimation, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, Turkey.
Evren ŞentürkDepartment of Anesthesiology and Intensive Care Medicine, School of Medicine, Koç University, Istanbul 34450, Turkey.ORCID 0000-0002-4985-562X
Uğur AksuBiology Department, Science Faculty, Istanbul University, Istanbul 34134, Turkey.ORCID 0000-0002-4134-3136
Pınar FıratDepartment of Pathology, School of Medicine, Koç University, Istanbul 34450, Turkey.
Perihan Ergin ÖzcanDepartment of Anesthesiology and Reanimation, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, Turkey.
Fevzi ToramanDepartment of Anesthesiology and Reanimation, School of Medicine, Acibadem University, Istanbul 34752, Turkey.ORCID 0000-0002-7455-6648
Mert ŞentürkDepartment of Anesthesiology and Reanimation, School of Medicine, Acibadem University, Istanbul 34752, Turkey.ORCID 0000-0003-2373-6451
On Behalf Of The Istanbul Research And Education In Anesthesia NETwork IREANETwork Experimental Working Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional endpoints may overlook pulmonary biological stress during abdominal mechanical loading and volume expansion. This controlled experimental study evaluated whether intra-abdominal hypertension (IAH), hypervolemia (HV), or their combination induces early pulmonary biochemical, permeability, oxidative-ischemic, inflammatory, and structural responses, with particular focus on surfactant protein A1 (SP-A1). Thirty-five male Wistar rats were randomized to Sham, HV, IAH, or IAH + HV groups. IAH was induced by CO

Indexed as

bronchoalveolar lavageendothelial glycocalyxhypervolemiainflammatory biomarkersintra-abdominal hypertensionoxidative stresspermeability indexpulmonary barriersurfactant protein A1

Identifiers

PMID42514277
PMCPMC13412432

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.