Evidence map›Paper›PMID 42514241›Full record

ArticleLife (Basel, Switzerland)2026

Stage-Dependent Reorganization of Inflammatory Biomarker Networks During Acute Exacerbations of COPD.

Larisa Alexandra Rus, Romana Olivia Popețiu, Simona Maria Borta, Nicolae Cătălin Hreniuc, Adrian Silviu Crișan, Carla Melania Tamaș, Evelin-Anda Laza, Paula Alexandra Vulciu, Oana Știrbu, Cecilia Avram and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Larisa Alexandra RusDepartment of Internal Medicine, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.ORCID 0009-0004-1281-9862
Romana Olivia PopețiuDepartment of Internal Medicine, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.ORCID 0009-0000-1192-1452
Simona Maria BortaDepartment of Internal Medicine, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.ORCID 0000-0002-2512-2691
Nicolae Cătălin HreniucArad County Emergency Clinical Hospital, Str. Andrényi Károly Nr. 24, 310037 Arad, Romania.ORCID 0000-0001-9824-3112
Adrian Silviu CrișanArad County Emergency Clinical Hospital, Str. Andrényi Károly Nr. 24, 310037 Arad, Romania.ORCID 0009-0002-4374-4248
Carla Melania TamașArad County Emergency Clinical Hospital, Str. Andrényi Károly Nr. 24, 310037 Arad, Romania.
Evelin-Anda LazaThe National Institute of Research-Development for Machines and Installations Designed for Agricultureand Food Industry (INMA), Bulevardul Ion Ionescu de la Brad 6, 013813 Bucharest, Romania.
Paula Alexandra VulciuDepartment of Biochemistry, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.
Oana ȘtirbuDepartment of Internal Medicine, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.
Cecilia AvramArad County Emergency Clinical Hospital, Str. Andrényi Károly Nr. 24, 310037 Arad, Romania.
Denisa GoldișArad County Emergency Clinical Hospital, Str. Andrényi Károly Nr. 24, 310037 Arad, Romania.
Darius Radu RomanDoctoral School of Biomedical Sciences, Faculty of Medicine, and Pharmacy, University of Oradea, Str. Universității Nr 1, 410087 Oradea, Romania.
Alexandru ChioreanuDepartment of Otorinolaryngology, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.
Radmila-Anca BugariDepartment of Otorinolaryngology, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.
Dana ZdremțanDepartment of Biochemistry, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.
Cristina Georgiana FiruDepartment of Heamatology, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.
Imola Donath-MiklosDepartment of Biology and Life Science, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.ORCID 0009-0009-9542-0035
Maria PușchițăDepartment of Internal Medicine, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are characterized by intensified systemic inflammation, yet the relationship between inflammatory biomarker profiles and underlying GOLD-defined airflow limitation severity remains incompletely understood. This exploratory cross-sectional study investigated inflammatory and hematological biomarkers across the spectrum of stable-state GOLD-defined airflow limitation severity in patients hospitalized for AECOPD. A total of 100 participants were included, comprising non-COPD controls and patients with mild-to-moderate (GOLD 1-2), severe (GOLD 3), and very severe (GOLD 4) COPD (

Indexed as

acute exacerbation of COPDairflow limitationbiomarker interactionsC-reactive proteindisease stratificationGOLD stagesinflammatory network remodelinginterleukin-6procalcitoninsystemic inflammation

Identifiers

PMID42514241
PMCPMC13413071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.