Comparison of Midazolam Plasma Concentrations in ARDS Patients with and Without ECMO Support-Prospective Observational Pilot Study.

Marek Grochla, Marcin Basiak, Bogusław Okopień, Ewa Trejnowska, Piotr Knapik

Abstract read

In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Marek GrochlaDepartment of Anesthesiology and Intensive Therapy in Zabrze, Medical University of Silesia in Katowice, Ul. Marii Skłodowskiej-Curie 9, 41-800 Zabrze, Poland.ORCID 0000-0001-6508-9307

Marcin BasiakDepartment of Internal Medicine and Clinical Pharmacology in Katowice, Medical University of Silesia in Katowice, Ul. Medyków 14, 40-752 Katowice, Poland.ORCID 0000-0003-0674-5612

Bogusław OkopieńDepartment of Internal Medicine and Clinical Pharmacology in Katowice, Medical University of Silesia in Katowice, Ul. Medyków 14, 40-752 Katowice, Poland.ORCID 0000-0001-7228-2906

Ewa TrejnowskaDepartment of Anesthesiology and Intensive Therapy in Zabrze, Medical University of Silesia in Katowice, Ul. Marii Skłodowskiej-Curie 9, 41-800 Zabrze, Poland.

Piotr KnapikDepartment of Anesthesiology and Intensive Therapy in Zabrze, Medical University of Silesia in Katowice, Ul. Marii Skłodowskiej-Curie 9, 41-800 Zabrze, Poland.

Funding

National Science Centre 525316

6 · The paper itself

Abstract

introductionPatients undergoing ECMO therapy have a much higher need for drug therapy due to the increased volume of distribution and deeper levels of sedation. The influence of ECMO support on the achieved midazolam concentrations is unknown. MATERIALS AND

methodsThis prospective, single-center study was conducted between October 2022 and December 2024. All mechanically ventilated patients with an FiO

resultsIn terms of demographic data, patients in group A were comparable to group B, except that patients in group A had a lower BMI (25.7 ± 5.1 kg/m

conclusionsThe use of probably higher doses of midazolam does not translate into higher plasma midazolam concentrations in ECMO patients.

Indexed as

ARDSdrug monitoringECMOICUmidazolam

Identifiers

PMID42514214

DOI10.3390/life16071144

PMCPMC13412589

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