Enhancing Bone Healing with a Priming Stimulus.

Michael Tanzer, Misghana Kassa, Nitin Chandra Teja Dadi, Tarek Klaylat, Rahul Gawri, Paul Martineau, Adam Hart

Abstract read

In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael TanzerDivision of Orthopaedic Surgery, McGill University, Montreal, QC H3G 1A4, Canada.ORCID 0000-0001-8986-6326

Misghana KassaJo Miller Orthopaedic Research Laboratory, McGill University Health Centre, Montreal, QC H3G 1A4, Canada.

Nitin Chandra Teja DadiJo Miller Orthopaedic Research Laboratory, McGill University Health Centre, Montreal, QC H3G 1A4, Canada.

Tarek KlaylatRegenerative Orthopaedics and Innovation Laboratory, McGill University Health Centre, Montreal, QC H3G 1A4, Canada.ORCID 0009-0004-6945-2459

Rahul GawriDivision of Orthopaedic Surgery, McGill University, Montreal, QC H3G 1A4, Canada.ORCID 0000-0001-9415-1739

Paul MartineauDivision of Orthopaedic Surgery, McGill University, Montreal, QC H3G 1A4, Canada.

Adam HartDivision of Orthopaedic Surgery, McGill University, Montreal, QC H3G 1A4, Canada.ORCID 0000-0001-9700-4523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone healing is a complex regenerative process regulated by interactions between skeletal and host biologic responses, and failure of bone repair remains a major challenge in orthopedic surgery. Using a murine model, this study investigated whether a preemptive priming stimulus could enhance healing of a subsequent contralateral cortical bone defect and whether the type and timing of the stimulus influenced this response. Skeletally mature male mice were randomized into six groups (

Indexed as

bone regenerationbone remodelingfemoral defectosteoimmunologypriming stimulustrained immunity

Identifiers

PMID42514181

DOI10.3390/life16071111

PMCPMC13413361

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.