ReviewLife (Basel, Switzerland)2026
Infraorbital Ethmoid Cells (Haller Cells) and Their Role in Chronic Rhinosinusitis: An Evidence-Based Meta-Analysis.
Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
15 authors.
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Abstract
backgroundHaller cells (HCs), infraorbital pneumatization of the anterior ethmoidal air cells, are anatomical variants frequently located adjacent to the maxillary sinus ostium. Their presence has been hypothesized to interfere with mucociliary drainage and contribute to the pathophysiology of chronic rhinosinusitis (CRS). Despite numerous imaging-based investigations, the etiological role of Haller cells in CRS remains uncertain. The aim of this meta-analysis is to highlight the association between HC and CRS using data derived from Computed Tomography (CT) and Cone-Beam Computed Tomography (CBCT) imaging. MATERIALS AND
methodsFollowing PRISMA guidelines and a registered protocol in the PROSPERO database, a systematic search across PubMed, EMBASE, and COCHRANE databases led to the inclusion of eight studies published between 2011 and 2024, comprising 2011 patients. The included studies employed multiplane reconstruction techniques and high-resolution imaging protocols. The majority of studies were retrospective, with only one adopting a prospective design.
resultsThe pooled odds ratio (OR) for the association between HC and CRS was 1.54 (95% Confidence Interval: 0.93-2.54;
conclusionsThese findings suggest that, while HC may play a role in CRS pathogenesis, the current evidence does not support a statistically significant association. Future prospective research using standardized imaging and diagnostic criteria is essential to clarify the clinical impact of HC in sinonasal disease.
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