Evidence map›Paper›PMID 42514111›Full record

ArticleLife (Basel, Switzerland)2026

The Curcumin Analogue PAC Induces Selective Apoptosis-Related Transcriptomic Reprogramming in Oral Squamous Carcinoma Cells.

Sara Benchekroun, Meriem Hammache, Fatiha Chandad, Mikhlid H Almutairi, Adam Daich, Mohammed Badwelan, Mahmoud Rouabhia, Abdelhabib Semlali

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sara BenchekrounGroupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Quebec, QC G1V 0A6, Canada.
Meriem HammacheGroupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Quebec, QC G1V 0A6, Canada.
Fatiha ChandadGroupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Quebec, QC G1V 0A6, Canada.ORCID 0000-0002-4415-0751
Mikhlid H AlmutairiDepartment of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-0337-6412
Adam DaichURCOM UR 3221, Université Le Havre Normandie, Normandie Université, 76600 Le Havre, France.ORCID 0000-0002-6942-0519
Mohammed BadwelanFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC H3A 0G4, Canada.ORCID 0000-0001-8101-0531
Mahmoud RouabhiaGroupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Quebec, QC G1V 0A6, Canada.ORCID 0000-0003-2205-8281
Abdelhabib SemlaliGroupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Quebec, QC G1V 0A6, Canada.ORCID 0000-0002-5797-8304

Funding

Fonds de Recherche du Québec - Nature et Technologies RiSBOdLaval University N/B
6 · The paper itself

Abstract

This study aimed to investigate the selective anticancer activity of the curcumin analog PAC (3,5-Bis-4-hydroxy-3-methoxybenzylidene)-N-methyl-4-piperidone). Normal gingival epithelial cells (GECs), cancerous gingival cells (Ca9-22) and tongue squamous carcinoma cells (CAL27) were exposed to increasing concentrations of PAC (0-10 µM) for 24 h. Cell viability and cytotoxicity were evaluated using MTT and LDH assays, while apoptosis and caspase activation were analyzed by Annexin V/PI staining and flow cytometry. Gene-expression profiling was performed using RT

Indexed as

apoptosiscaspasescurcumin analogoral squamous carcinomaPACselective anticancer activitytranscriptomic profiling

Identifiers

PMID42514111
PMCPMC13412525

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.