Evidence map›Paper›PMID 42514076›Full record

ArticleMicroorganisms2026

Structure-Guided Discovery of a Cold-Responsive Antifreeze-like Protein from Antarctic

Jennifer Charles Labo, Hui Yin Fan, Hackwon Do, Hoang Thi Ngoc Trang, Paris Lavin, Mohd Faizal Abu Bakar, Nur Athirah Yusof

Abstract read
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jennifer Charles LaboBiotechnology Research Institute, Universiti Malaysia Sabah, Kota Kinabalu 88450, Sabah, Malaysia.
Hui Yin FanFood Security Research Laboratory, Faculty of Food Science and Nutrition, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia.ORCID 0000-0002-2833-274X
Hackwon DoResearch Unit for Low-Temperature Convergence Technology, Korea Polar Research Institute, Incheon 21990, Republic of Korea.
Hoang Thi Ngoc TrangResearch Unit for Low-Temperature Convergence Technology, Korea Polar Research Institute, Incheon 21990, Republic of Korea.
Paris LavinDepartamento de Biotecnologia, Facultad de Ciencias del Mar y Recursos Biologicos, Universidad de Antofagasta, 601 Avenida Angamos, Antofagasta 1270300, Chile.ORCID 0000-0002-8893-526X
Mohd Faizal Abu BakarAdvanced Genomics and Bioinformatics, Malaysia Genome and Vaccine Institute, National Institutes of Biotechnology Malaysia, Jalan Bangi, Kajang 43000, Selangor, Malaysia.ORCID 0009-0000-3469-0597
Nur Athirah YusofBiotechnology Research Institute, Universiti Malaysia Sabah, Kota Kinabalu 88450, Sabah, Malaysia.ORCID 0000-0002-9298-7425

Funding

Yayasan Penyelidikan Antartika Sultan Mizan (YPASM) LPS2309
6 · The paper itself

Abstract

Antarctic microorganisms experience persistent subzero temperatures and repeated freeze-thaw cycles that require specialized mechanisms for survival. Although transcriptomic studies have identified numerous cold-responsive genes, many remain annotated as hypothetical proteins with unknown functions. In this study, we investigated PL002-1792, a strongly upregulated hypothetical protein from Antarctic

Indexed as

Antarctic microorganismsantifreeze-like proteincold adaptationFlavobacteriumhypothetical proteinsice-binding proteinice recrystallisation inhibition

Identifiers

PMID42514076
PMCPMC13413566

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.