Evidence map›Paper›PMID 42514064›Full record

ArticleMicroorganisms2026

Diagnostic and Microbiological Impact of Multiplex Syndromic Testing for Acute Infectious Gastroenteritis in a Regional Laboratory Network: A Real-World Before-After Study.

Massimiliano Guerra, Martina Brandolini, Laura Dionisi, Alessandra Mistral De Pascali, Ludovica Ingletto, Claudia Colosimo, Giulia Gatti, Maria Sofia Montanari, Anna Marzucco, Laura Grumiro and 5 more

Abstract read
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Massimiliano GuerraUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.ORCID 0009-0000-3654-7946
Martina BrandoliniUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.ORCID 0009-0002-1558-032X
Laura DionisiDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.
Alessandra Mistral De PascaliDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-8662-0782
Ludovica InglettoDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.ORCID 0009-0000-4771-8528
Claudia ColosimoDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.ORCID 0009-0001-4135-9402
Giulia GattiUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.ORCID 0000-0003-1907-8791
Maria Sofia MontanariDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.
Anna MarzuccoUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Laura GrumiroDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.
Giorgio DiraniUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.ORCID 0000-0001-7554-9653
Silvia ZannoliUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.ORCID 0000-0001-6296-505X
Alessandra ScagliariniDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.ORCID 0000-0003-1146-0101
Vittorio SambriUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.ORCID 0000-0002-5012-7355
Monica CriccaUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.ORCID 0000-0002-2815-3119

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute infectious gastroenteritis (AIG) is caused by diverse bacterial and viral enteric pathogens with overlapping clinical presentations, limiting conventional pathogen-directed workflows. This retrospective before-after study evaluated the diagnostic, microbiological, operational, and economic impact of multiplex molecular syndromic testing for AIG within a regional hub-and-spoke laboratory network in Italy. Two 19-month periods were compared: a pre-implementation period based on conventional diagnostics and a post-implementation period using multiplex syndromic panels as first-line tests. Diagnostic investigations totalled 25,574 before and 24,509 after implementation. Overall test positivity increased from 5.43% to 11.59% (

Indexed as

acute infectious gastroenteritiscost–consequence analysisdiagnostic yieldenteric bacterial pathogensenteric viral pathogenslaboratory workflowmolecular diagnosticsmultiplex PCRreal-world studysyndromic testing

Identifiers

PMID42514064
PMCPMC13413444

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.