Rethinking Vaginal Microbiome Resilience: A Conceptual Multi-Omic Framework.

Brittnee Cagle-White, Rob E Carpenter, Alaina Vincent, Ellen Kominek, Andrew Krouse

Abstract readReview

In one paragraph

Review in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brittnee Cagle-WhiteSchool of Medicine, The University of Texas at Tyler, 3900 University Boulevard, Tyler, TX 75799, USA.ORCID 0009-0008-7076-9946

Rob E CarpenterSoules College of Business, The University of Texas at Tyler, 3900 University Boulevard, Tyler, TX 75799, USA.

Alaina VincentOSPRI BioPath, 7290 Virginia Parkway, Suite 3400, McKinney, TX 75071, USA.

Ellen KominekOSPRI BioPath, 7290 Virginia Parkway, Suite 3400, McKinney, TX 75071, USA.

Andrew KrouseBusiness Operations & Facilities, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vaginal microbiome is often interpreted through static taxonomic patterns. Yet microbial composition alone does not explain why some communities resist perturbation, recover after disruption, or transition toward dysbiosis. This narrative review synthesizes evidence that vaginal microbiome stability is shaped by endocrine phase, epithelial substrate availability, microbial functional capacity, mucosal tone and candidate host modifiers. High-estrogen states, particularly pregnancy, are associated with epithelial maturation, glycogen accumulation, low vaginal pH, and

Indexed as

bacterial vaginosisestrogen–glycogen axisGardnerella diversitygenetic–hormonal interfacehost–microbe interactionsLactobacillus dominancevaginal microbiome

Identifiers

PMID42514041

DOI10.3390/microorganisms14071536

PMCPMC13414299

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.