ReviewJournal of clinical medicine2026
Effects of Nutritional Supplements on Vascular Function: A Narrative Review.
Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular aging is a key determinant of cardiovascular risk and is characterized by endothelial dysfunction, oxidative stress, inflammation, arterial stiffness, and alterations of the endothelial glycocalyx. In recent years, increasing scientific interest has focused on whether selected nutritional supplements can modulate these mechanisms. The objective of this narrative review is to summarize and critically evaluate the current evidence regarding the effects of selected nutritional supplements on endothelial function and vascular health, with emphasis on their proposed mechanisms of action, available preclinical and clinical evidence, and current limitations. This review examines nutritional supplements targeting nitric oxide biology (L-arginine/L-citrulline and citrulline derived from watermelon), polyphenol-rich foods and extracts (cocoa flavan-3-ols and grape polyphenols), mitochondrial redox balance (coenzyme Q10 and the mitochondria-targeted antioxidant MitoQ), endothelial glycocalyx-supporting formulations, olive-derived bioactive compounds, curcumin, and S-allyl cysteine. Across studies, improvements have been reported primarily in surrogate vascular endpoints, including flow-mediated dilation, pulse wave velocity, and blood pressure, although effect sizes vary and substantial heterogeneity exists among studies. Overall, current evidence suggests that several nutritional supplements may improve surrogate markers of vascular function; however, evidence demonstrating reductions in major cardiovascular events or cardiovascular mortality remains limited. Future research should prioritize adequately powered randomized controlled trials with longer follow-up, standardized supplement formulations, and clinically meaningful cardiovascular outcomes to more clearly define the role of nutritional supplements in cardiovascular prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.