Evidence map›Paper›PMID 42513222›Full record

ArticleMolecules (Basel, Switzerland)2026

Click Chemistry Approach to Derivatisation of Fluconazole.

Michał Janowski, Oleg M Demchuk, Sylwia Andrzejczuk, Angelika Pawlicka, Urszula Kosikowska, Marta Struga, Marcin Feldo, Monika Wujec

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michał JanowskiDoctoral School, Medical University of Lublin, Chodzki 7, 20-093 Lublin, Poland.ORCID 0009-0008-8016-0640
Oleg M DemchukFaculty of Medicine, The John Paul II Catholic University of Lublin, Konstantynów 1J, 20-708 Lublin, Poland.ORCID 0000-0002-5571-1593
Sylwia AndrzejczukDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki St., 20-093 Lublin, Poland.ORCID 0000-0001-6301-6059
Angelika PawlickaDepartment of Biochemistry, Faculty of Medicine, Medical University of Warsaw, Banacha St. 1, 02-097 Warsaw, Poland.ORCID 0009-0003-0751-2818
Urszula KosikowskaDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki St., 20-093 Lublin, Poland.ORCID 0000-0003-4536-1750
Marta StrugaDepartment of Biochemistry, Faculty of Medicine, Medical University of Warsaw, Banacha St. 1, 02-097 Warsaw, Poland.ORCID 0000-0002-0181-3607
Marcin FeldoDepartment of Vascular Surgery, Medical University of Lublin, Staszica 11 St., 20-081 Lublin, Poland.
Monika WujecDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4a Chodzki St., 20-093 Lublin, Poland.ORCID 0000-0001-9816-1934

Funding

National Science Centre 2019/33/B/NZ7/01608
6 · The paper itself

Abstract

The emergence of antimicrobial resistance necessitates the development of structurally novel agents with improved biological profiles. In this study, a series of new derivatives of fluconazole were designed, synthesized, and evaluated for antifungal activity. The synthetic approach involved esterification of hydroxyl group of fluconazole with an azide-group-containing benzoyl chloride, followed by copper-catalyzed azide-alkyne cycloaddition (CuAAC). The optimized catalytic system was based on a copper(I) catalyst generated from copper(II) palmitate and ascorbic acid. The transformations of the azide-containing derivatives were then performed. The obtained compounds were tested against reference strains of clinically relevant

Indexed as

Antifungal AgentsCandidaClick ChemistryFluconazoleAlkynesAzidesCatalysisCopperCycloaddition ReactionMicrobial Sensitivity TestsMolecular StructureAlkynesAntifungal AgentsAzidesCopperFluconazole1,2,3-triazoles1,2,4-triazolesantifungal agentsazide-alkyne Huisgen cycloadditionclick chemistrycopper catalysisCuAACdrug modificationfluconazole

Identifiers

PMID42513222
PMCPMC13415025

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.