ArticleMolecules (Basel, Switzerland)2026
Mechanochemical Synthesis of Valproic Acid-Based Hybrids: Antioxidant, Anti-Inflammatory, and In Silico Evaluation.
Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Valproic acid is a clinically important therapeutic agent whose biological properties have stimulated the development of structurally modified derivatives with improved pharmacological profiles. In the present study, nine amino-valproic acid hybrids were synthesized by a rapid mechanochemical approach using a planetary ball mill under solvent-minimized conditions. The synthesized compounds were formulated in a newly developed deep eutectic solvent composed of urea and propylene glycol (1:4 molar ratio), which was characterized by solvatochromic and Kamlet-Taft analyses. The biological activities of the derivatives were evaluated by hydrogen peroxide scavenging activity (HPSA), hydroxyl radical-scavenging activity (HRSA), and inhibition of albumin denaturation (IAD) assays. Among the investigated compounds, derivative
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