Evidence map›Paper›PMID 42513197›Full record

ReviewMolecules (Basel, Switzerland)2026

Microbial Inulinases: Characterization, Properties, and Potential Contribution to Metabolic and Nutritional Health.

Anca Daniela Raiciu, Mihaela-Carmen Eremia, Mariana Gratiela Vladu, Maria-Monica Petrescu, Dana-Maria Miu, Gabriela Valeria Săvoiu, Fawzia Sha'at, Ramona-Daniela Pavaloiu

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anca Daniela RaiciuDepartment of Pharmacognosy, Phytochemistry, and Phytotherapy, Faculty of Pharmacy, Titu Maiorescu University, Gh. Şincai Street No.16, District 4, 040314 Bucharest, Romania.ORCID 0000-0001-8671-0705
Mihaela-Carmen EremiaNational Institute for Chemical-Pharmaceutical Research and Development (ICCF), 112 Vitan Av., District 3, 031299 Bucharest, Romania.ORCID 0000-0002-2906-6148
Mariana Gratiela VladuNational Institute for Chemical-Pharmaceutical Research and Development (ICCF), 112 Vitan Av., District 3, 031299 Bucharest, Romania.ORCID 0000-0002-8784-3400
Maria-Monica PetrescuNational Institute for Chemical-Pharmaceutical Research and Development (ICCF), 112 Vitan Av., District 3, 031299 Bucharest, Romania.ORCID 0000-0001-8747-8573
Dana-Maria MiuNational Institute for Chemical-Pharmaceutical Research and Development (ICCF), 112 Vitan Av., District 3, 031299 Bucharest, Romania.
Gabriela Valeria SăvoiuNational Institute for Chemical-Pharmaceutical Research and Development (ICCF), 112 Vitan Av., District 3, 031299 Bucharest, Romania.
Fawzia Sha'atNational Institute for Chemical-Pharmaceutical Research and Development (ICCF), 112 Vitan Av., District 3, 031299 Bucharest, Romania.ORCID 0000-0002-1028-0822
Ramona-Daniela PavaloiuNational Institute for Chemical-Pharmaceutical Research and Development (ICCF), 112 Vitan Av., District 3, 031299 Bucharest, Romania.

Funding

Ministry of Education and Research, UEFISCDI PN-IV-P7-7.1-PED-2024-0703, no. 30PED/2025
6 · The paper itself

Abstract

Microbial inulinases are enzymes produced by bacteria, yeasts, and fungi that can hydrolyze inulin into fructose and fructooligosaccharides (FOSs). The article discusses the various types of inulinases (exo- and endo-inulinases), microbial sources, biochemical properties, and optimal activity conditions, which are critical for their use in biotechnological and food processes. Special emphasis is placed on inulin degradation products, particularly FOSs, which are known for their prebiotic properties. They promote the growth of beneficial intestinal microbiota, helping to maintain digestive health and improve nutrient absorption. Compounds produced by inulinases may play an important role in the prevention of metabolic diseases such as obesity, type 2 diabetes mellitus, and dyslipidemias by modulating the microbiota and regulating energy metabolism. In conclusion, microbial inulinases are a promising biotechnological tool for developing nutritional strategies to prevent metabolic diseases and improve overall health. Recent evidence demonstrates that advances in recombinant expression systems, enzyme engineering, immobilization technologies, and microbiome research have substantially expanded the industrial and biomedical potential of microbial inulinases. This review highlights emerging trends toward sustainable enzyme production, precision nutrition, and microbiome-targeted functional foods while identifying current limitations and future research priorities.

Indexed as

BacteriaGlycoside HydrolasesAnimalsHumansInulinOligosaccharidesPrebioticsfructooligosaccharideGlycoside HydrolasesInulininulinaseOligosaccharidesPrebioticsFOSinulinmetabolic diseasesmicrobial inulinaseprebiotics

Identifiers

PMID42513197
PMCPMC13416181

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.