In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Kaique Gonçalves de SouzaResearch Laboratory of Natural Products and Bioactive Molecules, (Lab Nat-UFF) Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo 28625-650, RJ, Brazil.
Larissa Saviani RibeiroResearch Laboratory of Natural Products and Bioactive Molecules, (Lab Nat-UFF) Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo 28625-650, RJ, Brazil.ORCID 0009-0005-2946-2203 Vitor Guimarães LourençoResearch Laboratory of Natural Products and Bioactive Molecules, (Lab Nat-UFF) Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo 28625-650, RJ, Brazil.ORCID 0009-0003-5854-3796 Kevin Costa MirandaLaboratory of Natural Products Technology, Department of Pharmaceutical Technology, School of Pharmacy, Fluminense Federal University, Niterói 24241-000, RJ, Brazil.ORCID 0000-0003-3963-9285 Francisco Paiva MachadoLaboratory of Natural Products Technology, Department of Pharmaceutical Technology, School of Pharmacy, Fluminense Federal University, Niterói 24241-000, RJ, Brazil.ORCID 0000-0002-5332-9972 Mariana Toledo Martins PereiraResearch Laboratory of Natural Products and Bioactive Molecules, (Lab Nat-UFF) Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo 28625-650, RJ, Brazil.
Leandro RochaLaboratory of Natural Products Technology, Department of Pharmaceutical Technology, School of Pharmacy, Fluminense Federal University, Niterói 24241-000, RJ, Brazil.ORCID 0000-0003-0484-1918 Vinicius D'Avila Bitencourt PascoalResearch Laboratory of Natural Products and Bioactive Molecules, (Lab Nat-UFF) Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo 28625-650, RJ, Brazil.ORCID 0000-0002-9009-1190 Aislan Cristina Rheder Fagundes PascoalResearch Laboratory of Natural Products and Bioactive Molecules, (Lab Nat-UFF) Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo 28625-650, RJ, Brazil.ORCID 0000-0002-4234-4843 Funding
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/210.576/2025
6 · The paper itselfAbstract
background
methodsThis study characterized the essential oil from
resultsGC-MS analysis identified 23 compounds, representing 91.41% of the oil composition, with predominance of oxygenated sesquiterpenes. The major constituents were globulol (15.71%), α-selinene (13.14%), selin-11-en-4-α-ol (8.31%), cubeban-11-ol (8.04%), and β-elemene (6.78%). The essential oil showed no significant cytotoxicity below 100 micrograms/mL toward RAW 264.7 macrophages and significantly reduced LPS-induced TNF-α and IL-1β gene expression. In vivo, it markedly inhibited paw edema induced by carrageenan, compound 48/80, and bradykinin, but not by prostaglandin E
conclusionsThese findings demonstrate that
Indexed as
Anti-Inflammatory AgentsEugeniaOils, VolatileAnimalsCarrageenanDisease Models, AnimalEdemaGas Chromatography-Mass SpectrometryLipopolysaccharidesMacrophagesMaleMicePlant LeavesRAW 264.7 CellsAnti-Inflammatory AgentsCarrageenanLipopolysaccharidesOils, Volatileacute inflammationessential oilEugenia involucrataIL-1βTNF-α
Identifiers
PMID42513156
PMCPMC13415304
What OpenQuestion holds
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LicenceCC BY
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