Evidence map›Paper›PMID 42513142›Full record

ReviewMolecules (Basel, Switzerland)2026

Advances in Research on

Li Yuan, Yang-En Sun, Ya-Peng Liang, Da-Hong Yao, Ya-Ping Guo, Xun Song, Zhen-Dan He, Bing Zhao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li YuanCollege of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China.
Yang-En SunShandong Key Laboratory of Gelatine Medicines Research and Development, Dong'e Ejiao Co., Ltd., No. 78, Ejiao Street, Liaocheng 252201, China.
Ya-Peng LiangShandong Key Laboratory of Gelatine Medicines Research and Development, Dong'e Ejiao Co., Ltd., No. 78, Ejiao Street, Liaocheng 252201, China.
Da-Hong YaoCollege of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China.
Ya-Ping GuoCollege of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China.
Xun SongCollege of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China.ORCID 0000-0002-2566-3519
Zhen-Dan HeCollege of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China.
Bing ZhaoShandong Key Laboratory of Gelatine Medicines Research and Development, Dong'e Ejiao Co., Ltd., No. 78, Ejiao Street, Liaocheng 252201, China.

Funding

Basic Research Fund in Shenzhen Natural Science Foundation JCYJ20241202124709013Centrally Government Guided Local Science and Technology Development Fund Project YDZX2023090China University of Science and Technology 2025ZD1801402Dong'e Ejiao Fund Project DEEJ-YB-2023-12-112Innovation Team Project of Guangdong Provincial Department of Education 2024KCXTD012
6 · The paper itself

Abstract

ethnopharmacological relevanceAIM OF THE STUDY: This narrative review aims to provide a comprehensive and critical overview of the phytochemical constituents, pharmacological activities, and underlying mechanisms of MATERIALS AND

methodsThe literature was searched in PubMed, Web of Science, ScienceDirect, CNKI and Wanfang Data from database inception to December 2025. The combined retrieval keywords were set as: (

resultsPhytochemical studies have identified diverse secondary metabolites, particularly steroidal saponins, along with diarylheptanoids and phenanthrenes. These compounds exhibit multiple pharmacological activities, including anti-inflammatory, anti-tumor, immunomodulatory, and cardioprotective effects. Mechanistic studies indicate that these activities are mediated through the modulation of key signaling pathways such as NF-κB, PI3K/Akt, AMPK, and the NLRP3 inflammasome. However, current research remains fragmented, with limited integration of chemical composition, molecular targets, and therapeutic outcomes.

conclusions

Indexed as

DioscoreaPhytochemicalsPlant ExtractsAnimalsAnti-Inflammatory AgentsHumansAnti-Inflammatory AgentsPhytochemicalsPlant Extractsanti-inflammatory activityDioscorea nipponicasteroidal saponinstraditional medicine

Identifiers

PMID42513142
PMCPMC13415829

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.