ArticleMolecules (Basel, Switzerland)2026
The Environmental Occurrence of Pharmaceutical Residues, Agrochemical Contaminants, and Antimicrobial Resistance in a Wastewater-Impacted Urban Water System: A One Health Assessment.
Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Urban water security in many cities in the Global South is increasingly challenged by ageing infrastructure and the presence of persistent chemical contaminants. This study investigated the Harare metropolitan water continuum between 2020 and 2024 using a longitudinal, systems-oriented observational framework encompassing wastewater discharge, surface water reservoirs, drinking water treatment, and municipal distribution networks. A three-stage approach was employed, comprising qualitative screening for selected pharmaceuticals at the Lake Chivero water-sediment interface in 2020, spatial assessment of physicochemical stability across the treatment and distribution system in 2021, and targeted qualitative evaluation of pharmaceutical and agrochemical occurrence in wastewater-impacted matrices in 2024. Sulfamethoxazole and trimethoprim were qualitatively identified using high-performance liquid chromatography (HPLC), while atrazine was confirmed by gas chromatography-mass spectrometry (GC-MS). These analyses indicated the continued presence of pharmaceutical and agrochemical residues within wastewater-impacted aquatic compartments associated with the Harare water supply. Physicochemical monitoring revealed elevated ammonia concentrations and reduced free residual chlorine across sections of the distribution network. These conditions coincided with detectable heterotrophic bacterial regrowth at distal consumer endpoints. Phenotypic antimicrobial susceptibility testing of bacterial isolates recovered at the source interface showed limited inhibition responses to sulfamethoxazole and trimethoprim under the experimental conditions used. While the observational nature of this study precludes causal inference, the co-occurrence of chemical residues, physicochemical instability, and bacterial isolates exhibiting reduced inhibition responses highlights conditions of potential relevance for antimicrobial resistance risk within wastewater-influenced urban water systems. These findings underscore the importance of integrated water management strategies addressing wastewater control, source water protection, and distribution system integrity within a One Health context.
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