Evidence map›Paper›PMID 42512991›Full record

ReviewMicromachines2026

Recent Advances in Paper-Based Microfluidic Devices for Heavy Metal Ion Detection: A Review.

Jianqin Xu, Xinyuan Ma, Zhiping Li, Tingting Zhou, Yanshuang Wang, Jianyu Zhu

Abstract readReview
In one paragraph

Review in Micromachines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jianqin XuSchool of Basic Medical Sciences, Beihua University, Jilin City 132013, China.ORCID 0009-0000-1275-9178
Xinyuan MaSchool of Stomatology, Shanxi Medical University, Taiyuan 030001, China.
Zhiping LiJilin City People's Hospital, Jilin City 132011, China.
Tingting ZhouCollege of Medical Technology, Beihua University, Jilin City 132013, China.
Yanshuang WangSchool of Basic Medical Sciences, Beihua University, Jilin City 132013, China.
Jianyu ZhuSchool of Basic Medical Sciences, Beihua University, Jilin City 132013, China.ORCID 0009-0005-0494-7685

Funding

Jilin Province Science and Technology Development Plan Project 20240303047NCScience and Technology Research Project of the Jilin Provincial Department of Education JJKH20230077KJ
6 · The paper itself

Abstract

Heavy metal ion pollution has emerged as a global issue. These contaminants are not only present in water sources but are also commonly detected in air, soil, food, and consumer products, posing serious risks to ecosystems and human health. Even at very low concentrations, heavy metal ions can exhibit substantial toxicity. Traditional methods for the detection of heavy metal ions typically require complex laboratory equipment and specialized technicians, making them inadequate for rapid on-site monitoring. Microfluidic technology, as an innovative platform capable of precisely controlling and manipulating minute volumes of fluid, has demonstrated enormous potential in analytical chemistry, biomedicine, and environmental monitoring. In the rapidly developing field of microfluidics, paper-based microfluidic platforms have become prominent due to their low cost, straightforward fabrication, and eco-friendly nature, offering powerful tools for the detection of heavy metal ions in diverse samples. This survey consolidates the major advances reported from 2015 to 2025 in utilizing paper-based microfluidic systems for identifying heavy metal ion pollutants in diverse sample types, including air, explosive residues, water sources, herbal supplements, skin-whitening cosmetics, environmental aerosols, urine, soil, gunshot residues, cucumber plants, and food. The review analyzes in detail the principles and applications of detection strategies based on colorimetric methods, fluorescent methods, electrochemical methods, dual-detection systems, and other methods, as well as the role of nanomaterials and selective recognition elements in improving detection sensitivity and specificity. These portable, low-cost, and easy-to-operate detection systems provide viable solutions for environmental and public health monitoring, particularly suitable for resource-limited regions and scenarios requiring rapid detection.

Indexed as

colorimetric detectiondetection of heavy metal ionsdouble detection systemelectrochemical detectionfluorescence detectionpaper-based microfluidics

Identifiers

PMID42512991
PMCPMC13414290

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.