ArticleMicromachines2026
Response Surface Methodology-Optimized Synthesis of ZIF-8 Nanoparticles and Its Application in the Extraction of Anthraquinones from Cassia Seed.
Article in Micromachines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In this study, response surface methodology (RSM) was employed to evaluate and optimize the key parameters for the solvothermal synthesis of Zeolitic Imidazolate Framework-8 (ZIF-8) nanoparticles, including solvent type, reaction temperature, reaction time, and material ratio. A multivariate regression model identified the optimal preparation conditions as ethanol as the solvent, a reaction temperature of 120 °C, a reaction time of 4 h, and a 5:1 molar ratio of 2-methylimidazole to zinc acetate. The resulting ZIF-8 nanoparticles exhibited highly selective adsorption capacity toward anthraquinones and were successfully applied to the rapid extraction and detection of five anthraquinones from Cassiae semen. By investigating the adsorbent dosage, adsorption efficiency, elution solvent, and elution efficiency, we established the optimal experimental conditions. Briefly, 20 mg of ZIF-8 nanoparticles were added to 10 mL of Cassia semen extract, and the mixture was shaken for 10 min before centrifugation. The residual anthraquinones in the supernatant were quantified by Ultra Performance Liquid Chromatography (UPLC). The adsorption efficiencies of aloe-emodin, rhein, emodin, chrysophanol, and physcion were 80.2%, 93.8%, 100%, 100%, and 100%, respectively. When eluted with methanol/100 mM NaHCO
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