Evidence map›Paper›PMID 42512529›Full record

ReviewBrain sciences2026

NTS Neural Subtypes and Satiety Pathways: taVNS as a Novel Neuromodulatory Intervention.

Hanyu Deng, Chen Xin, Haohan Zhu, Xinjiang Zhang, Lan Sun, Yanfeng Zheng, Peijing Rong

Abstract readReview
In one paragraph

Review in Brain sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hanyu DengInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.ORCID 0009-0004-0347-9026
Chen XinInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Haohan ZhuInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Xinjiang ZhangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Lan SunInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yanfeng ZhengInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Peijing RongInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Funding

Beijing Traditional Chinese Medicine Science and Technology Development Fund Youth Project BJZYQN-2025-07Multidisciplinary Innovative Team of Traditional Chinese Medicine, National Administration of Traditional Chinese Medicine ZYYCXTD-D-202409Qihuang Scholar of the National TCM Leading Talents Support Program ZZ202219005Special Project for Cultivating Outstanding Young Scientific and Technological Talents, Basic Scientific Research Fund, China Academy of Chinese Medical Sciences ZZ19-YQ-036Young Scientists Fund (Category C), National Natural Science Foundation of China 82505784
6 · The paper itself

Abstract

The global obesity epidemic has become one of the most severe public health challenges of the 21st century, and existing treatment strategies have limitations such as poor long-term adherence, significant side effects, or high invasiveness. Dysregulation of feeding behavior is the core driver of obesity, and its precise regulation depends on the complete transmission of gut-brain axis signals. The nucleus of the solitary tract (NTS), as the first central relay station for visceral afferent signals, is a key hub for the regulation of feeding homeostasis. This article reviews the peripheral signal transduction mechanisms of hunger and satiety, the core afferent pathway of the vagus nerve, and the functional heterogeneity of neuron subpopulations within the NTS, focusing on the anatomical basis, neuroimaging evidence, and preclinical and clinical research progress of transcutaneous auricular vagus nerve stimulation (taVNS) targeting the NTS to exert anti-obesity effects. Accumulating evidence suggests that taVNS may modulate the activity of satiety-promoting neurons and attenuate aberrant hyperactivity of TH

Indexed as

feeding homeostasisneuronal subpopulationsnucleus of the solitary tractobesitysatietytranscutaneous auricular vagus nerve stimulation

Identifiers

PMID42512529
PMCPMC13406153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.