ArticleCancers2026
Integrative Multi-Transcriptomic Uncovers Actionable Signatures and Drug Repurposing Candidates for ccRCC-Hypertension Comorbidity.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHypertension is a common comorbidity and risk factor for clear cell renal cell carcinoma (ccRCC), yet the molecular mechanisms linking these two diseases remain unclear. This study aimed to investigate hypertension-related molecular signatures in ccRCC using integrated multi-transcriptomic analyses.
methodHypertension-related differentially expressed genes (DEHRGs) in ccRCC were identified by integrating transcriptomic data from the TCGA-KIRC cohort with the GeneCards database. Functional enrichment, WGCNA, machine learning, GSVA, survival analysis, and Mendelian randomization were performed to identify and characterize hub genes. Spatial and single-cell transcriptomic analyses were used to investigate tumor heterogeneity and predict candidate therapeutic compounds, which were subsequently evaluated in vitro.
resultsFour hypertension-related hub genes-
conclusionsThis study systematically characterized hypertension-related molecular signatures in ccRCC and identified
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