Evidence map›Paper›PMID 42512223›Full record

SynthesisInternational journal of environmental research and public health2026

Laser Auriculotherapy for Anxiety Symptoms Across Diverse Populations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Hernán Andrés de la Barra Ortiz, Claudio Chamorro Lange, Nivaldo Antonio Parizotto, Richard Eloin Liebano

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in International journal of environmental research and public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Efficacy of auriculotherapy in reducing pain: a comprehensive literature review.Frontiers in pain research (Lausanne, Switzerland) · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hernán Andrés de la Barra OrtizExercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile.ORCID 0000-0002-3927-1743
Claudio Chamorro LangeExercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile.ORCID 0000-0002-6703-8842
Nivaldo Antonio ParizottoInstitute of Advanced and Strategic Studies (IEAE), Federal University of São Carlos, São Carlos 13565-905, SP, Brazil.ORCID 0000-0003-1774-9053
Richard Eloin LiebanoDepartment of Rehabilitation Sciences, University of Hartford, West Hartford, CT 06117, USA.

Funding

Andrés Bello University DI-03-25/CBC
6 · The paper itself

Abstract

Anxiety disorders are highly prevalent conditions associated with substantial psychosocial burden, and low-level laser therapy auriculotherapy (LLLT-AT) has emerged as a non-invasive intervention with potential neuromodulatory effects for anxiety management. This systematic review aimed to evaluate the effects of LLLT-AT on anxiety symptoms across diverse populations. The review was conducted according to PRISMA 2020 guidelines and prospectively registered in PROSPERO (CRD420251159376). Randomized controlled trials comparing LLLT-AT with sham, placebo, or active interventions were identified through searches in PubMed, Web of Science, Scopus, CINAHL, MEDLINE, ScienceDirect, Cochrane Library, PEDro, and Google Scholar. The literature search was last updated on 2 July 2026. Risk of bias was assessed using RoB 2 and certainty of evidence using GRADE. Six RCTs involving 386 participants were included. Meta-analysis suggested significant reductions in post-treatment anxiety symptoms favoring LLLT-AT compared with control interventions (SMD = -0.65; 95% CI: -1.17 to -0.13), although substantial heterogeneity was identified (I

Indexed as

AnxietyAnxiety DisordersAuriculotherapyLow-Level Light TherapyHumansRandomized Controlled Trials as Topicanxiety disordersauriculotherapylow-level laser therapyphotobiomodulation therapyrandomized controlled trials

Identifiers

PMID42512223
PMCPMC13410117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.