Evidence map›Paper›PMID 42512135›Full record

ArticleInternational journal of environmental research and public health2026

Acute and Chronic Toxicity of Ketoprofen Active Pharmaceutical Ingredient and Commercial Formulations to the Freshwater Photosynthetic Species

Gabriel Souza-Silva, Maria I G A Silva, Anna C B Miranda, Mariângela Domingos Alcântara, Cléssius R Souza, Micheline Rosa Silveira

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriel Souza-SilvaFaculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.
Maria I G A SilvaFaculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.
Anna C B MirandaFaculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.
Mariângela Domingos AlcântaraFaculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.
Cléssius R SouzaFaculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.
Micheline Rosa SilveiraFaculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.

Funding

Brazilian Federal Agency for Support and Evaluation of Graduate Education 3CSRD VA 1National Council for Scientific and Technological Development 2
6 · The paper itself

Abstract

Ketoprofen (KET) is a non-steroidal anti-inflammatory drug frequently detected in surface waters and effluents, with the potential to impact trophic base organisms. This study evaluated the toxicity of KET, in its active pharmaceutical ingredient (API) form and in four commercial formulations (KET-1, KET-2, KET-3, and KET-4), on two freshwater species: the cyanobacterium

Indexed as

Anti-Inflammatory Agents, Non-SteroidalChlorella vulgarisKetoprofenMicrocystisWater Pollutants, ChemicalBulk DrugsFresh WaterToxicity Tests, AcuteAnti-Inflammatory Agents, Non-SteroidalBulk DrugsKetoprofenWater Pollutants, Chemicalanti-inflammatorycyanobacteriaemerging contaminantenvironmental healthmicroalgaepharmaceutical waste

Identifiers

PMID42512135
PMCPMC13409918

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.