Evidence map›Paper›PMID 42512001›Full record

ReviewBiomedicines2026

Natural Compounds in Pediatric Disease Treatment.

Dmitry O Ivanov, Roman O Shaikenov, Svetlana N Morozkina, Petr P Snetkov, Ruslan A Nasyrov, Polina G Serbun, Anna D Kosova, Alexander G Shavva, Igor M Kvetnoy

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dmitry O IvanovDepartment of Neonatology, Department of Pathology, Saint Petersburg State Pediatric Medical University, Litovskaya Str., 2, 194110 Saint Petersburg, Russia.
Roman O ShaikenovInstitute of Advanced Data Transfer Systems, ITMO University, Kronverkskiy Pr., 49, Bldg. A, 197101 Saint Petersburg, Russia.
Svetlana N MorozkinaInstitute of Advanced Data Transfer Systems, ITMO University, Kronverkskiy Pr., 49, Bldg. A, 197101 Saint Petersburg, Russia.ORCID 0000-0003-0122-0251
Petr P SnetkovInstitute of Advanced Data Transfer Systems, ITMO University, Kronverkskiy Pr., 49, Bldg. A, 197101 Saint Petersburg, Russia.ORCID 0000-0001-9949-5709
Ruslan A NasyrovDepartment of Neonatology, Department of Pathology, Saint Petersburg State Pediatric Medical University, Litovskaya Str., 2, 194110 Saint Petersburg, Russia.ORCID 0000-0001-8120-2816
Polina G SerbunInstitute of Advanced Data Transfer Systems, ITMO University, Kronverkskiy Pr., 49, Bldg. A, 197101 Saint Petersburg, Russia.
Anna D KosovaInstitute of Advanced Data Transfer Systems, ITMO University, Kronverkskiy Pr., 49, Bldg. A, 197101 Saint Petersburg, Russia.
Alexander G ShavvaInstitute of Medicine, Saint Petersburg State University, Universitetskaya Emb., 7-9, 199034 Saint Petersburg, Russia.
Igor M KvetnoyDepartment of Neonatology, Department of Pathology, Saint Petersburg State Pediatric Medical University, Litovskaya Str., 2, 194110 Saint Petersburg, Russia.ORCID 0000-0001-7302-5581

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The review evaluates current clinical and epidemiological evidence regarding the use of plant-derived compounds in pediatric practice. Data from randomized controlled trials indicate symptomatic efficacy of selected agents-particularly in acute respiratory infections-alongside generally favorable safety profiles when standardized preparations are used. Emerging research also explores applications in neurodevelopmental disorders, gastrointestinal conditions, and dermatology, and as supportive therapy in pediatric oncology. However, variability in product quality, limited pediatric-specific trials, potential toxicity, and regulatory inconsistencies remain significant challenges. The integration of phytotherapy into pediatric care therefore requires rigorous study design, careful safety monitoring, and clear quality standards to ensure an evidence-based risk-benefit balance.

Indexed as

clinical trials in pediatricsherbal medicinemedicinal plantsnatural compoundspediatric phytotherapypediatric therapy

Identifiers

PMID42512001
PMCPMC13404584

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.