Evidence map›Paper›PMID 42511848›Full record

ArticleInternational journal of molecular sciences2026

Sodium Butyrate-Assisted Induction of Posterior Pre-Neural Progenitors from Pluripotent Stem Cells.

Kyung Taek Oh, Deok Ho Kim, Wonjun Hong, Kyoungmin Park, Hakyoung You, Cheol-Koo Lee, Chulhong Oh, Gun-Hoo Park, Seungkwon You

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kyung Taek OhLaboratory of Cell Function Regulation, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Deok Ho KimLaboratory of Functional Genomics, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Wonjun HongLaboratory of Cell Function Regulation, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Kyoungmin ParkLaboratory of Cell Function Regulation, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.ORCID 0009-0003-5645-4415
Hakyoung YouLaboratory of Functional Genomics, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Cheol-Koo LeeLaboratory of Functional Genomics, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Chulhong OhKorea Institute of Ocean Science & Technology, 2670, Iljudong-ro, Gujwa-eup, Jeju-si 63349, Jeju-do, Republic of Korea.ORCID 0000-0002-9283-3258
Gun-Hoo ParkKorea Institute of Ocean Science & Technology, 2670, Iljudong-ro, Gujwa-eup, Jeju-si 63349, Jeju-do, Republic of Korea.ORCID 0000-0001-7860-3459
Seungkwon YouLaboratory of Cell Function Regulation, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.

Funding

Structure Of Beta Amyloid FibrilsZ01EB000010 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI LEAPMAN, RICHARD · 2007 to 2008
$9k
Intramural NIH HHS Z01 EB000010Korea Institute of Ocean Science and Technology PEB0010Korean Fund for Regenerative Medicine(KFRM) grant funded by the korea government (the Ministry of Science and ICT, the Ministry of Health & Welfare) 23A0204L1the Korea university Grant K2520291
6 · The paper itself

Abstract

Posterior axis development during mammalian embryogenesis is driven by transient progenitor states that give rise to neural and mesodermal lineages, including neuromesodermal progenitors (NMPs). In vitro derivation of posterior progenitor populations from human pluripotent stem cells (hPSCs) has relied on modulation of Wnt and FGF signaling; however, these approaches frequently generate heterogeneous and unstable cell populations. Here, we investigated whether sodium butyrate (NaB) supplementation could promote a posteriorly biased intermediate state without extensive extracellular signaling control. We show that NaB, a histone deacetylase inhibitor, promotes the induction of posterior pre-neural progenitors (PNPs) characterized by co-expression of CDX2 and SOX2, together with suppression of SOX1. Transcriptomic analyses revealed that NaB-treated cells exhibit a posteriorly enriched PNPs with restrained anterior neural differentiation, transient early

Indexed as

Butyric AcidNeural Stem CellsPluripotent Stem CellsCell DifferentiationGene Expression Regulation, DevelopmentalHumansTretinoinButyric AcidTretinoinposterior neural developmentpre-neural progenitorssodium butyrateventral motor neuron development

Identifiers

PMID42511848
PMCPMC13409835

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.